In Silico and In Vitro Studies for Benzimidazole Anthelmintics Repurposing as VEGFR‑2 Antagonists: Novel Mebendazole-Loaded Mixed Micelles with Enhanced Dissolution and Anticancer Activity

• Ayman Abo Elmaaty,
• Khaled M. Darwish,
• Amani Chrouda,
• Amira A. Boseila,
• Mohamed A. Tantawy,
• Sameh S. Elhady,
• Afzal B. Shaik,
• Muhamad Mustafa,
• Ahmed A. Al-karmalawy

Affiliations

Ayman Abo Elmaaty

Department of Medicinal Chemistry, Faculty of Pharmacy, Port Said University, Port Said, Egypt

Khaled M. Darwish

Department of Medicinal Chemistry, Faculty of Pharmacy, Suez Canal University, Ismailia, Egypt

Amani Chrouda

Department of Chemistry, College of Science Al-Zulfi, Majmaah University, Al-Majmaah, Saudi Arabia

Amira A. Boseila

Pharmaceutics Department, Egyptian Drug Authority EDA (Formerly Known as National Organization for Drug Control and Research NODCAR) Dokki, Giza, Egypt

Mohamed A. Tantawy

Hormones Department, Medical Research Division, National Research Centre, Giza, Egypt

Sameh S. Elhady

Department of Natural Products, Faculty of Pharmacy, King Abdulaziz University, Jeddah, Saudi Arabia

Afzal B. Shaik

Department of Pharmaceutical Chemistry, Vignan Pharmacy College, Jawaharlal Nehru Technological University, Vadlamudi, Andhra Pradesh, India

Muhamad Mustafa

Department of Medicinal Chemistry, Deraya University, Minia, Egypt

Ahmed A. Al-karmalawy

Department of Pharmaceutical Medicinal Chemistry, Faculty of Pharmacy, Horus University-Egypt, New Damietta, Egypt