Future Science OA (Jun 2021)

Survival and glycemic control in patients with co-existing squamous cell carcinoma and diabetes mellitus

  • Sophia A Ederaine,
  • Johanny Lopez Dominguez,
  • Jamison A Harvey,
  • Aaron R Mangold,
  • Curtiss B Cook,
  • Heidi Kosiorek,
  • Matthew Buras,
  • Kyle Coppola,
  • Nina J Karlin

DOI
https://doi.org/10.2144/fsoa-2020-0150
Journal volume & issue
Vol. 7, no. 5

Abstract

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Aim: This study examined the impact of diabetes mellitus (DM) on survival in squamous cell carcinoma (SCC) patients, and the impact of SCC on glycemic control. Materials & methods: Patients with newly diagnosed SCC with and without DM were matched 1:1 (2007–2017). Overall survival and recurrence-free survival were estimated using the Kaplan–Meier method. Hemoglobin A1c (HbA1c) and glucose level during the year following cancer diagnosis were compared using mixed models. Results: HbA1c decreased over time in DM patients (p = 0.04). The 5-year overall survival was 61% in DM patients, compared with 78% in patients without DM (p = 0.004). Conclusion: The presence of co-existing DM adversely impacted survival in patients with SCC. SCC did not affect glycemic control.

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