Inflammatory Markers and Aortic Aneurysms: Exploring the Role of Hs-CRP and MHR in Ascending Aortic Aneurysm Development

Abstract

Diyar Köprülü,1 Mohamed Omar Hassan,2 Hüsnü Atmaca,3 Sezgin Albayrak,1 Esra Işcanlı4 1Department of Cardiology, Ordu State Hospital, Ordu, Turkey; 2Department of Cardiology, Mogadishu Somali Turkish Training and Research Hospital, Mogadishu, Somalia; 3Department of Cardiology, Samsun Gazi State Hospital, Samsun, Turkey; 4Department of Radiology, Ankara Bilkent Sehir Hospital, Ankara, TurkeyCorrespondence: Diyar Köprülü, Email [email protected]: Aortic aneurysms, particularly those affecting the ascending aorta, pose significant health risks due to their potential to cause life-threatening complications such as rupture and dissection. While the etiology of ascending aortic aneurysms has traditionally been associated with non-inflammatory processes, emerging evidence suggests a potential role of inflammation in their development.Methods: This study investigates the relationship between inflammatory markers and ascending aortic aneurysms, focusing on high-sensitivity C-reactive protein (hs-CRP) and the monocyte-to-HDL ratio (MHR). A total of 135 patients with ascending aortic aneurysms and 40 control subjects underwent comprehensive evaluations, including echocardiography, computed tomography imaging, and serum biomarker measurements.Results: The results indicate significantly elevated levels of hs-CRP and MHR in patients with ascending aortic aneurysms compared to the control group, suggesting a potential inflammatory component in the pathogenesis of these aneurysms. However, the precise mechanisms underlying this association remain to be elucidated.Conclusion: Despite limitations such as the cross-sectional study design and relatively small sample size, this study provides valuable insights into the potential involvement of inflammation in ascending aortic aneurysms. Further research, including longitudinal studies and histopathological analysis of aortic tissue, is warranted to confirm these findings and explore the utility of inflammatory markers as diagnostic and prognostic indicators in this patient population.Keywords: ascending aortic aneurysm, inflammation, hs-CRP, monocyte-to-HDL ratio

Keywords

• ascending aortic aneurysm
• inflammation
• hs-crp
• monocyte-to-hdl ratio.