Nature Communications (Mar 2021)

T-cell CX3CR1 expression as a dynamic blood-based biomarker of response to immune checkpoint inhibitors

  • Takayoshi Yamauchi,
  • Toshifumi Hoki,
  • Takaaki Oba,
  • Vaibhav Jain,
  • Hongbin Chen,
  • Kristopher Attwood,
  • Sebastiano Battaglia,
  • Saby George,
  • Gurkamal Chatta,
  • Igor Puzanov,
  • Carl Morrison,
  • Kunle Odunsi,
  • Brahm H. Segal,
  • Grace K. Dy,
  • Marc S. Ernstoff,
  • Fumito Ito

DOI
https://doi.org/10.1038/s41467-021-21619-0
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 14

Abstract

Read online

There is an urgent need to discover blood-based biomarkers to predict response to immune checkpoint inhibitors (ICI). Here the authors show that effective ICI therapy correlates with increased frequency of circulating CX3CR1+CD8+ T cells in preclinical tumor models and in a cohort of patients with non-small cell lung cancer treated with anti-PD-1.