Massive true thymic hyperplasia with osseous metaplasia

Jun Kanzawa, MD; Mitsuru Matsuki, MD, PhD; Shintaro Kano, MD; Akihiro Nakamata, MD; Waka Nakata, MD, PhD; Rieko Furukawa, MD; Katsuhisa Baba, MD; Shigeru Ono, MD, PhD; Harushi Mori, MD, PhD

Radiology Case Reports (Jun 2023)

Massive true thymic hyperplasia with osseous metaplasia

Jun Kanzawa, MD,
Mitsuru Matsuki, MD, PhD,
Shintaro Kano, MD,
Akihiro Nakamata, MD,
Waka Nakata, MD, PhD,
Rieko Furukawa, MD,
Katsuhisa Baba, MD,
Shigeru Ono, MD, PhD,
Harushi Mori, MD, PhD

Affiliations

Jun Kanzawa, MD: Department of Radiology, Jichi Medical University, 3311-1 Yakushiji, Shimotsuke-shi, Tochigi-ken, 329-0498, Japan; Corresponding author.
Mitsuru Matsuki, MD, PhD: Department of Pediatric Medical Imaging, Jichi Children's Medical Center Tochigi, 3311-1 Yakushiji, Shimotsuke-shi, Tochigi-ken, 329-0498, Japan
Shintaro Kano, MD: Department of Radiology, Jichi Medical University, 3311-1 Yakushiji, Shimotsuke-shi, Tochigi-ken, 329-0498, Japan
Akihiro Nakamata, MD: Department of Radiology, Jichi Medical University, 3311-1 Yakushiji, Shimotsuke-shi, Tochigi-ken, 329-0498, Japan
Waka Nakata, MD, PhD: Department of Pediatric Medical Imaging, Jichi Children's Medical Center Tochigi, 3311-1 Yakushiji, Shimotsuke-shi, Tochigi-ken, 329-0498, Japan
Rieko Furukawa, MD: Department of Pediatric Medical Imaging, Jichi Children's Medical Center Tochigi, 3311-1 Yakushiji, Shimotsuke-shi, Tochigi-ken, 329-0498, Japan
Katsuhisa Baba, MD: Department of Pediatric Surgery, Jichi Children's Medical Center Tochigi, 3311-1 Yakushiji, Shimotsuke-shi, Tochigi-ken, 329-0498, Japan
Shigeru Ono, MD, PhD: Department of Pediatric Surgery, Jichi Children's Medical Center Tochigi, 3311-1 Yakushiji, Shimotsuke-shi, Tochigi-ken, 329-0498, Japan
Harushi Mori, MD, PhD: Department of Radiology, Jichi Medical University, 3311-1 Yakushiji, Shimotsuke-shi, Tochigi-ken, 329-0498, Japan

Journal volume & issue: Vol. 18, no. 6
pp. 2307 – 2310

Abstract

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True thymic hyperplasia is defined as an increase in both the size and weight of the gland, while maintaining a normal microscopic architecture. Massive true thymic hyperplasia is a rare type of hyperplasia that compresses adjacent structures and causes various symptoms.Limited reports address the imaging findings of massive true thymic hyperplasia. Herein, we report a case of massive true thymic hyperplasia in a 3-year-old girl with no remarkable medical history. Contrast-enhanced CT revealed an anterior mediastinal mass with a bilobed configuration containing punctate and linear calcifications in curvilinear septa, which corresponded to lamellar bone deposits in the interlobular septa. To our knowledge, this is the first report of massive true thymic hyperplasia with osseous metaplasia. We also discuss the imaging features and etiology of massive true thymic hyperplasia with osseous metaplasia.

Published in Radiology Case Reports

ISSN: 1930-0433 (Online)
Publisher: Elsevier
Country of publisher: United States
LCC subjects: Medicine: Medicine (General): Medical physics. Medical radiology. Nuclear medicine
Website: https://www.sciencedirect.com/journal/radiology-case-reports

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