Nature Communications (Aug 2018)
FOXD1-dependent MICU1 expression regulates mitochondrial activity and cell differentiation
- Santhanam Shanmughapriya,
- Dhanendra Tomar,
- Zhiwei Dong,
- Katherine J. Slovik,
- Neeharika Nemani,
- Kalimuthusamy Natarajaseenivasan,
- Edmund Carvalho,
- Christy Lu,
- Kaitlyn Corrigan,
- Venkata Naga Srikanth Garikipati,
- Jessica Ibetti,
- Sudarsan Rajan,
- Carlos Barrero,
- Kurt Chuprun,
- Raj Kishore,
- Salim Merali,
- Ying Tian,
- Wenli Yang,
- Muniswamy Madesh
Affiliations
- Santhanam Shanmughapriya
- Department of Medical Genetics and Molecular Biochemistry, Lewis Katz School of Medicine at Temple University
- Dhanendra Tomar
- Department of Medical Genetics and Molecular Biochemistry, Lewis Katz School of Medicine at Temple University
- Zhiwei Dong
- Department of Medical Genetics and Molecular Biochemistry, Lewis Katz School of Medicine at Temple University
- Katherine J. Slovik
- Institute for Regenerative Medicine, University of Pennsylvania
- Neeharika Nemani
- Department of Medical Genetics and Molecular Biochemistry, Lewis Katz School of Medicine at Temple University
- Kalimuthusamy Natarajaseenivasan
- Department of Medical Genetics and Molecular Biochemistry, Lewis Katz School of Medicine at Temple University
- Edmund Carvalho
- Department of Medical Genetics and Molecular Biochemistry, Lewis Katz School of Medicine at Temple University
- Christy Lu
- Department of Medical Genetics and Molecular Biochemistry, Lewis Katz School of Medicine at Temple University
- Kaitlyn Corrigan
- Department of Medical Genetics and Molecular Biochemistry, Lewis Katz School of Medicine at Temple University
- Venkata Naga Srikanth Garikipati
- Center for Translational Medicine, Lewis Katz School of Medicine at Temple University
- Jessica Ibetti
- Center for Translational Medicine, Lewis Katz School of Medicine at Temple University
- Sudarsan Rajan
- Department of Medical Genetics and Molecular Biochemistry, Lewis Katz School of Medicine at Temple University
- Carlos Barrero
- Department of Pharmaceutical Sciences, Temple University
- Kurt Chuprun
- Center for Translational Medicine, Lewis Katz School of Medicine at Temple University
- Raj Kishore
- Center for Translational Medicine, Lewis Katz School of Medicine at Temple University
- Salim Merali
- Department of Pharmaceutical Sciences, Temple University
- Ying Tian
- Center for Translational Medicine, Lewis Katz School of Medicine at Temple University
- Wenli Yang
- Institute for Regenerative Medicine, University of Pennsylvania
- Muniswamy Madesh
- Department of Medical Genetics and Molecular Biochemistry, Lewis Katz School of Medicine at Temple University
- DOI
- https://doi.org/10.1038/s41467-018-05856-4
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 12
Abstract
Genetic ablation of Mitochondrial Ca2+ uptake protein 1 (MICU1) in mouse induces higher rates of perinatal lethality. Here the authors show that MICU1 expression is regulated by hypoxia in a FOXD1-dependent manner, establishing a cyclic switch between glycolytic and oxidative metabolism during development.
