Does Natalizumab Induce or Aggravate Psoriasis? A Case Study and Review of the Literature

Abstract

Psoriasis is a relatively common immune-mediated chronic inflammatory skin disease. It is well known that interferon-beta, a drug used in the management of relapsing-remitting multiple sclerosis, could exacerbate or induce de novo psoriasis. There is limited evidence in the literature based only on case reports that natalizumab could induce or aggravate psoriasis. In this case study, we present a 33-year-old patient who developed plaque psoriasis during natalizumab treatment.

Keywords

• Natalizumab
• Psoriasis
• Autoimmune disease
• Multiple sclerosis
• Th17 cell