Characteristics of patients with acute over chronic liver failure (ACLF) and risk of mortality due to amount of alcohol, MELD and MELD NA

Abstract

Introduction and Objective: To assess patients with ACLF, MELD and MELDNA scales and the amount of alcohol consumption as predictors of mortality. Materials and Methods: Retrospective, analytical, and retrolective study, the records of patients who met the criteria of ACLF, age, gender, cause of liver disease, degree of ACLF, alcohol consumption, MELD and MELDNA were reviewed, descriptive and inferential statistics were performed, RR was calculated with a p< 0.5. Results: We included 88 patients, 23 women (26%) and 65 men (74%) of alcoholic origin 62 (70%) and non-alcoholic 26 (30%). By grade of ACLF, 26 (30%) grade I, 41 (47%) grade II, and 21 (24%) grade III. Mortality of 40 (45%), grade I 9 (23%), grade II 17 (43%), and grade III 14 (35%). Deaths in the alcohol group 25 (62.5%) and non-alcohol 15 (37.5%). Pearson correlation calculation was performed death p=0.21 with R1, for MELD NA p=0.15 R2 and MELD p=.003 R3. The grams of alcohol ingested per day ranged from 30 to 1600, with a median of 120. Discussion: Patients with ACLF in our population are mostly men, of alcoholic origin, with mortality in grade 2 of ACLF of 45%, which is high. The correlation was made with the amount of alcohol they consumed, without finding that it is a factor that impacts the development of ACFL or mortality; this suggests that the inflammatory response is multifactorial, as well as its outcome. The MELD scale better predicts mortality risk. Conclusions: The amount of alcohol in our population does not increase the risk of mortality. Funding: The resources used in this study were from the hospital without any additional financing Declaration of interest: The authors declare no potential conflicts of interest.