Nature Communications (Feb 2017)
microRNA-17 family promotes polycystic kidney disease progression through modulation of mitochondrial metabolism
- Sachin Hajarnis,
- Ronak Lakhia,
- Matanel Yheskel,
- Darren Williams,
- Mehran Sorourian,
- Xueqing Liu,
- Karam Aboudehen,
- Shanrong Zhang,
- Kara Kersjes,
- Ryan Galasso,
- Jian Li,
- Vivek Kaimal,
- Steven Lockton,
- Scott Davis,
- Andrea Flaten,
- Joshua A. Johnson,
- William L. Holland,
- Christine M. Kusminski,
- Philipp E. Scherer,
- Peter C. Harris,
- Marie Trudel,
- Darren P. Wallace,
- Peter Igarashi,
- Edmund C. Lee,
- John R. Androsavich,
- Vishal Patel
Affiliations
- Sachin Hajarnis
- Department of Internal Medicine and Division of Nephrology, University of Texas Southwestern Medical Center
- Ronak Lakhia
- Department of Internal Medicine and Division of Nephrology, University of Texas Southwestern Medical Center
- Matanel Yheskel
- Department of Internal Medicine and Division of Nephrology, University of Texas Southwestern Medical Center
- Darren Williams
- Department of Internal Medicine and Division of Nephrology, University of Texas Southwestern Medical Center
- Mehran Sorourian
- Regulus Therapeutics Inc.
- Xueqing Liu
- Regulus Therapeutics Inc.
- Karam Aboudehen
- Department of Medicine and Division of Nephrology, University of Minnesota Medical School
- Shanrong Zhang
- Advanced Imaging Research Center, University of Texas Southwestern Medical Center
- Kara Kersjes
- Regulus Therapeutics Inc.
- Ryan Galasso
- Regulus Therapeutics Inc.
- Jian Li
- Regulus Therapeutics Inc.
- Vivek Kaimal
- Regulus Therapeutics Inc.
- Steven Lockton
- Regulus Therapeutics Inc.
- Scott Davis
- Regulus Therapeutics Inc.
- Andrea Flaten
- Department of Internal Medicine and Division of Nephrology, University of Texas Southwestern Medical Center
- Joshua A. Johnson
- Department of Internal Medicine and Touchstone Diabetes Center, University of Texas Southwestern Medical Center
- William L. Holland
- Department of Internal Medicine and Touchstone Diabetes Center, University of Texas Southwestern Medical Center
- Christine M. Kusminski
- Department of Internal Medicine and Touchstone Diabetes Center, University of Texas Southwestern Medical Center
- Philipp E. Scherer
- Department of Internal Medicine and Touchstone Diabetes Center, University of Texas Southwestern Medical Center
- Peter C. Harris
- Department of Nephrology and Hypertension, Mayo College of Medicine
- Marie Trudel
- Molecular Genetics and Development, Institut de Recherches Cliniques de Montreal, Universite de Montreal, Faculte de Medecine
- Darren P. Wallace
- Department of Medicine and the Kidney Institute, University of Kansas Medical Center
- Peter Igarashi
- Department of Medicine and Division of Nephrology, University of Minnesota Medical School
- Edmund C. Lee
- Regulus Therapeutics Inc.
- John R. Androsavich
- Regulus Therapeutics Inc.
- Vishal Patel
- Department of Internal Medicine and Division of Nephrology, University of Texas Southwestern Medical Center
- DOI
- https://doi.org/10.1038/ncomms14395
- Journal volume & issue
-
Vol. 8,
no. 1
pp. 1 – 15
Abstract
Autosomal dominant polycystic kidney disease (ADPKD) is a life-threatening genetic disease that leads to renal failure. Here Hajarniset al. show that miR-17 modulates cyst progression in ADPKD through metabolic reprogramming of mitochondria and its inhibition slows cyst development and improves renal functions.
