Nature Communications (Jan 2021)
Dynamics of genome architecture and chromatin function during human B cell differentiation and neoplastic transformation
- Roser Vilarrasa-Blasi,
- Paula Soler-Vila,
- Núria Verdaguer-Dot,
- Núria Russiñol,
- Marco Di Stefano,
- Vicente Chapaprieta,
- Guillem Clot,
- Irene Farabella,
- Pol Cuscó,
- Marta Kulis,
- Xabier Agirre,
- Felipe Prosper,
- Renée Beekman,
- Silvia Beà,
- Dolors Colomer,
- Hendrik G. Stunnenberg,
- Ivo Gut,
- Elias Campo,
- Marc A. Marti-Renom,
- José Ignacio Martin-Subero
Affiliations
- Roser Vilarrasa-Blasi
- Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS)
- Paula Soler-Vila
- CNAG-CRG, Centre for Genomic Regulation (CRG), Barcelona Institute of Science and Technology (BIST)
- Núria Verdaguer-Dot
- Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS)
- Núria Russiñol
- Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS)
- Marco Di Stefano
- CNAG-CRG, Centre for Genomic Regulation (CRG), Barcelona Institute of Science and Technology (BIST)
- Vicente Chapaprieta
- Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS)
- Guillem Clot
- Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS)
- Irene Farabella
- CNAG-CRG, Centre for Genomic Regulation (CRG), Barcelona Institute of Science and Technology (BIST)
- Pol Cuscó
- Gastrointestinal and Endocrine Tumors Group, Vall d’Hebron Institute of Oncology (VHIO)
- Marta Kulis
- Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS)
- Xabier Agirre
- Centro de Investigación Biomédica en Red de Cáncer (CIBERONC)
- Felipe Prosper
- Centro de Investigación Biomédica en Red de Cáncer (CIBERONC)
- Renée Beekman
- Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS)
- Silvia Beà
- Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS)
- Dolors Colomer
- Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS)
- Hendrik G. Stunnenberg
- Molecular Biology, NCMLS, FNWI, Radboud University
- Ivo Gut
- CNAG-CRG, Centre for Genomic Regulation (CRG), Barcelona Institute of Science and Technology (BIST)
- Elias Campo
- Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS)
- Marc A. Marti-Renom
- CNAG-CRG, Centre for Genomic Regulation (CRG), Barcelona Institute of Science and Technology (BIST)
- José Ignacio Martin-Subero
- Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS)
- DOI
- https://doi.org/10.1038/s41467-020-20849-y
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 18
Abstract
The dynamics of genome architecture during human cell differentiation and upon neoplastic transformation remain poorly characterized. Here, the authors integrate in situ Hi-C and nine additional omic layers to characterize the dynamic changes in 3D genome architecture during normal B cell differentiation and in neoplastic cells from chronic lymphocytic leukemia and mantle cell lymphoma patients.
