An epigenome atlas of neural progenitors within the embryonic mouse forebrain

Christopher T. Rhodes; Joyce J. Thompson; Apratim Mitra; Dhanya Asokumar; Dongjin R. Lee; Daniel J. Lee; Yajun Zhang; Eva Jason; Ryan K. Dale; Pedro P. Rocha; Timothy J. Petros

doi:10.1038/s41467-022-31793-4

Nature Communications (Jul 2022)

An epigenome atlas of neural progenitors within the embryonic mouse forebrain

Christopher T. Rhodes,
Joyce J. Thompson,
Apratim Mitra,
Dhanya Asokumar,
Dongjin R. Lee,
Daniel J. Lee,
Yajun Zhang,
Eva Jason,
Ryan K. Dale,
Pedro P. Rocha,
Timothy J. Petros

Affiliations

Christopher T. Rhodes: Unit on Cellular and Molecular Neurodevelopment, Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), National Institutes of Health (NIH)
Joyce J. Thompson: Unit on Genome Structure and Regulation, Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), National Institutes of Health (NIH)
Apratim Mitra: Bioinformatics and Scientific Programming Core, Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), National Institutes of Health (NIH)
Dhanya Asokumar: Unit on Cellular and Molecular Neurodevelopment, Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), National Institutes of Health (NIH)
Dongjin R. Lee: Unit on Cellular and Molecular Neurodevelopment, Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), National Institutes of Health (NIH)
Daniel J. Lee: Unit on Cellular and Molecular Neurodevelopment, Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), National Institutes of Health (NIH)
Yajun Zhang: Unit on Cellular and Molecular Neurodevelopment, Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), National Institutes of Health (NIH)
Eva Jason: Bioinformatics and Scientific Programming Core, Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), National Institutes of Health (NIH)
Ryan K. Dale: Bioinformatics and Scientific Programming Core, Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), National Institutes of Health (NIH)
Pedro P. Rocha: Unit on Genome Structure and Regulation, Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), National Institutes of Health (NIH)
Timothy J. Petros: Unit on Cellular and Molecular Neurodevelopment, Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), National Institutes of Health (NIH)

DOI: https://doi.org/10.1038/s41467-022-31793-4
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 17

Abstract

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The authors took a multimodal approach to characterize the differential transcriptome and epigenetic landscape between distinct regions of the embryonic mouse forebrain, revealing many unexplored presumptive promoter-enhancer interactions.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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