Case Reports in Oncology (Apr 2023)

Case Report: Evolutionary Clinical-Radiological Features of a Diffuse Hemispheric Glioma, H3 G34 Mutant with Over 5 Years of Survival

  • Camilla A.F. Yamada,
  • Matheus Soldatelli,
  • Lázaro Luis Faria do Amaral,
  • Christiane Monteiro de Siqueira Campos,
  • Paulo Lazaro de Moraes,
  • Feres Eduardo Aparecido Chaddad-Neto,
  • Carmen Lucia Penteado Lancellotti

DOI
https://doi.org/10.1159/000530181
Journal volume & issue
Vol. 16, no. 1
pp. 279 – 286

Abstract

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Diffuse hemispheric glioma (DHG), H3 G34 mutant was included in the 5th edition of the World Health Organization Classification of Tumors of the Central Nervous System recently published. Given the recent inclusion in the current classification and its rarity in adult patients, there are scarce data on clinical-radiological characteristics, survival, and outcome. The authors report the case of a 35-year-old female with DHG, H3 G34-mutant characteristics and outcomes with an unusual presentation, recurrence, and prolonged survival. In conclusion, our case report demonstrates relevant details that should be observed in patients with suspicion or confirmation of the diagnosis of DHG, H3 G34 mutant, not only in the initial presentation but also in the evolution to ensure more personalized treatment.

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