Outer Membrane Structural Defects in Salmonella enterica Serovar Typhimurium Affect Neutrophil Chemokinesis but Not Chemotaxis

Abstract

Neutrophils are the first responders to invading pathogens; thus, understanding their migratory response to live pathogens is crucial. We developed a microfluidic assay that separates bacteria from phagocytic neutrophils while maintaining chemical communication between the two populations.