Nature Communications (Nov 2022)

Deep learning-based image analysis predicts PD-L1 status from H&E-stained histopathology images in breast cancer

  • Gil Shamai,
  • Amir Livne,
  • António Polónia,
  • Edmond Sabo,
  • Alexandra Cretu,
  • Gil Bar-Sela,
  • Ron Kimmel

DOI
https://doi.org/10.1038/s41467-022-34275-9
Journal volume & issue
Vol. 13, no. 1
pp. 1 – 13

Abstract

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Programmed death ligand-1 (PD-L1) has been recently adopted for breast cancer as a predictive biomarker for immunotherapies. Here, the authors show that PD-L1 expression can be predicted from H&E-stained images using deep learning.