Bone marrow-derived epithelial cells and hair follicle stem cells contribute to development of chronic cutaneous neoplasms

Heuijoon Park; Sonali Lad; Kelsey Boland; Kelly Johnson; Nyssa Readio; Guangchun Jin; Samuel Asfaha; Kelly S. Patterson; Ashok Singh; Xiangdong Yang; Douglas Londono; Anupama Singh; Carol Trempus; Derek Gordon; Timothy C. Wang; Rebecca J. Morris

doi:10.1038/s41467-018-07688-8

Nature Communications (Dec 2018)

Bone marrow-derived epithelial cells and hair follicle stem cells contribute to development of chronic cutaneous neoplasms

Heuijoon Park,
Sonali Lad,
Kelsey Boland,
Kelly Johnson,
Nyssa Readio,
Guangchun Jin,
Samuel Asfaha,
Kelly S. Patterson,
Ashok Singh,
Xiangdong Yang,
Douglas Londono,
Anupama Singh,
Carol Trempus,
Derek Gordon,
Timothy C. Wang,
Rebecca J. Morris

Affiliations

Heuijoon Park: Department of Pathology and Cell Biology, Columbia University
Sonali Lad: The Hormel Institute, University of Minnesota
Kelsey Boland: The Hormel Institute, University of Minnesota
Kelly Johnson: The Hormel Institute, University of Minnesota
Nyssa Readio: The Hormel Institute, University of Minnesota
Guangchun Jin: Division of Digestive and Liver Diseases, Department of Medicine and Irving Cancer Center, Columbia University
Samuel Asfaha: Division of Digestive and Liver Diseases, Department of Medicine and Irving Cancer Center, Columbia University
Kelly S. Patterson: Division of Digestive and Liver Diseases, Department of Medicine and Irving Cancer Center, Columbia University
Ashok Singh: The Hormel Institute, University of Minnesota
Xiangdong Yang: Division of Digestive and Liver Diseases, Department of Medicine and Irving Cancer Center, Columbia University
Douglas Londono: Department of Genetics, Rutgers, The State University of New Jersey
Anupama Singh: The Hormel Institute, University of Minnesota
Carol Trempus: Matrix Biology Group, Immunity, Inflammation, and Disease Laboratory, National Institute of Environmental Health Sciences
Derek Gordon: Department of Genetics, Rutgers, The State University of New Jersey
Timothy C. Wang: Division of Digestive and Liver Diseases, Department of Medicine and Irving Cancer Center, Columbia University
Rebecca J. Morris: Department of Pathology and Cell Biology, Columbia University

DOI: https://doi.org/10.1038/s41467-018-07688-8
Journal volume & issue: Vol. 9, no. 1
pp. 1 – 15

Abstract

Read online

Bone marrow-derived epithelial cells can be recruited to sites of chronic inflammation. Here, the authors using allogenic bone marrow transplantation in a multistage murine cutaneous carcinogenesis model show that bone marrow-derived epithelial cells and hair follicle stem cells are recruited to cutaneous neoplasms during tumor promotion of carcinogen-exposed skin and bone marrow.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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