Tunable, biodegradable grafting-from glycopolypeptide bottlebrush polymers

Zachary S. Clauss; Casia L. Wardzala; Austin E. Schlirf; Nathaniel S. Wright; Simranpreet S. Saini; Bibiana Onoa; Carlos Bustamante; Jessica R. Kramer

doi:10.1038/s41467-021-26808-5

Nature Communications (Nov 2021)

Tunable, biodegradable grafting-from glycopolypeptide bottlebrush polymers

Zachary S. Clauss,
Casia L. Wardzala,
Austin E. Schlirf,
Nathaniel S. Wright,
Simranpreet S. Saini,
Bibiana Onoa,
Carlos Bustamante,
Jessica R. Kramer

Affiliations

Zachary S. Clauss: Department of Biomedical Engineering, University of Utah
Casia L. Wardzala: Department of Biomedical Engineering, University of Utah
Austin E. Schlirf: Department of Biomedical Engineering, University of Utah
Nathaniel S. Wright: Department of Biomedical Engineering, University of Utah
Simranpreet S. Saini: Department of Biomedical Engineering, University of Utah
Bibiana Onoa: Howard Hughes Medical Institute University of California Berkeley
Carlos Bustamante: Howard Hughes Medical Institute University of California Berkeley
Jessica R. Kramer: Department of Biomedical Engineering, University of Utah

DOI: https://doi.org/10.1038/s41467-021-26808-5
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 11

Abstract

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Synthetic mimics of glycoproteins and proteoglycans have wide applications in biomedicine, yet preparation has been challenged by their high grafting and glycosylation densities. Here the authors show one-pot dual-catalysis polymerization of glycan-bearing α-amino acid N-carboxyanhydrides to form glycopolypeptide brushes.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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