Oxygen saturation imaging as a useful tool for visualizing the mode of action of photodynamic therapy for esophageal cancer

Masayuki Suyama, MD, PhD; Yusuke Yoda, MD; Yoichi Yamamoto, MD, PhD; Hironori Sunakawa, MD; Tatsunori Minamide, MD; Keisuke Hori, MD, PhD; Hiroaki Ikematsu, MD, PhD; Tomonori Yano, MD, PhD

VideoGIE (Oct 2020)

Oxygen saturation imaging as a useful tool for visualizing the mode of action of photodynamic therapy for esophageal cancer

Masayuki Suyama, MD, PhD,
Yusuke Yoda, MD,
Yoichi Yamamoto, MD, PhD,
Hironori Sunakawa, MD,
Tatsunori Minamide, MD,
Keisuke Hori, MD, PhD,
Hiroaki Ikematsu, MD, PhD,
Tomonori Yano, MD, PhD

Affiliations

Masayuki Suyama, MD, PhD: Department of Gastroenterology and Endoscopy, National Cancer Center Hospital East, Kashiwa, Japan
Yusuke Yoda, MD: Department of Gastroenterology and Endoscopy, National Cancer Center Hospital East, Kashiwa, Japan
Yoichi Yamamoto, MD, PhD: Department of Gastroenterology and Endoscopy, National Cancer Center Hospital East, Kashiwa, Japan
Hironori Sunakawa, MD: Department of Gastroenterology and Endoscopy, National Cancer Center Hospital East, Kashiwa, Japan
Tatsunori Minamide, MD: Department of Gastroenterology and Endoscopy, National Cancer Center Hospital East, Kashiwa, Japan
Keisuke Hori, MD, PhD: Department of Gastroenterology and Endoscopy, National Cancer Center Hospital East, Kashiwa, Japan
Hiroaki Ikematsu, MD, PhD: Department of Gastroenterology and Endoscopy, National Cancer Center Hospital East, Kashiwa, Japan
Tomonori Yano, MD, PhD: Department of Gastroenterology and Endoscopy, National Cancer Center Hospital East, Kashiwa, Japan

Journal volume & issue: Vol. 5, no. 10
pp. 496 – 499

Abstract

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Background and aims: Oxygen saturation (OS) imaging is a novel technique that directly measures and visualizes the tissue oxygen saturation at the surface of the GI tract. Our purpose was to evaluate the ability of OS imaging to visualize the action mode of photodynamic therapy (PDT). Methods: Eight patients with local recurrence after chemoradiotherapy for esophageal cancer were enrolled. OS imaging observation was performed before PDT, after 100 J/cm2 illumination and illumination completion, and on the second day. Results: OS imaging showed an extreme change in the hypoxic state in the illuminated area, although the change was near invisible on white-light imaging. The median tissue oxygen saturation value at the tumor lesion was 61.5% (range, 36%-91%) before PDT and significantly decreased immediately after illumination: 11% (range, 0%-57%) after 100 J/cm2 illumination, 1% (range, 0%-6%) at PDT completion, and 2% (range, 0%-12%) on the second day. Conclusions: OS imaging could be a useful tool to visualize changes after PDT.

Published in VideoGIE

ISSN: 2468-4481 (Online)
Publisher: Elsevier
Country of publisher: United States
LCC subjects: Medicine: Internal medicine: Specialties of internal medicine: Diseases of the digestive system. Gastroenterology
Website: https://www.sciencedirect.com/journal/videogie

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