Nature Communications (May 2019)

Kappa chain maturation helps drive rapid development of an infant HIV-1 broadly neutralizing antibody lineage

  • Cassandra A. Simonich,
  • Laura Doepker,
  • Duncan Ralph,
  • James A. Williams,
  • Amrit Dhar,
  • Zak Yaffe,
  • Lauren Gentles,
  • Christopher T. Small,
  • Brian Oliver,
  • Vladimir Vigdorovich,
  • Vidya Mangala Prasad,
  • Ruth Nduati,
  • D. Noah Sather,
  • Kelly K. Lee,
  • Frederick A. Matsen IV,
  • Julie Overbaugh

DOI
https://doi.org/10.1038/s41467-019-09481-7
Journal volume & issue
Vol. 10, no. 1
pp. 1 – 12

Abstract

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Development of broadly neutralizing antibodies (bnAb) against HIV-1 in infected adults is a multi-step process unachievable by current vaccine approaches. Here the authors reconstruct the ontogeny of an infant bnAb, which develops in fewer steps, and identify its unique features that may shorten the path to HIV vaccines.