Metaplastic Carcinoma Breast with Chondroid Differentiation: A Rare Case Report and Review of Literature

Abstract

Metaplastic carcinoma of the breast is a rare tumour. Though metaplastic carcinoma is by itself a rare entity, however metaplastic carcinoma with chondroid differentiation makes it even rarer. These tumours are ER, PR, HER2 negative (triple negative) and portend poor prognosis. Present case is of 30 year female, presented in Surgery Department with painless lump in upper outer quadrant and was advised ultrasonography. Ultrasonography revealed a neoplastic lesion. She underwent modified radical mastectomy and specimen was sent to the Department of Pathology. Specimen measures 12 x 12 x 3 cm in size. On cutting, a grey white firm mass measuring 2 x 2 x 1.5 cm was noted. On microscopy the diagnosis of metaplastic carcinoma with chondroid differentiation was made which was further confirmed by IHC showing ER, PR and HER2 negative and positivity for EGFR, CK5/6 and S100.

Keywords

• lump
• modified radical mastectomy
• triple negative