ASSESSMENT OF ANTIARRHYTHMIC ACTIVITY AND SAFETY OF NEW DERIVATIVES OF MORPHOLINOACETIC ACID

Abstract

Study of the anti-arrhythmic influence of the new organic synthesis’s products was the purpose of an actual research. Such characteristics of these compounds as acute toxicity, anti-arrhythmic and pro-arrhythmic activity were studied. The mostly strongly marked effect was discovered while using M-0 and M-18. These compounds showed the highest anti-arrhythmic activity and the lowest toxicity. It was also discovered that M-18 compound is less dangerous than M-0 one due to absence of the certainly expressed spill-over effect of an arrhythmogenic action.

Keywords

• arrhythmia
• acute toxicity
• effective antiarrhythmic dose
• arrhythmogenic effect