Journal of Microbiology, Immunology and Infection (Dec 2021)

In vitro activity of arbekacin against multidrug-resistant gram-negative bacilli

  • Mariana Albano,
  • Wim Alexander Fleischmann,
  • Kerryl E. Greenwood-Quaintance,
  • Robin Patel

Journal volume & issue
Vol. 54, no. 6
pp. 1118 – 1121

Abstract

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Background: Arbekacin is a broad-spectrum aminoglycoside with activity against some Gram-positive and Gram-negative bacteria. Methods: Arbekacin minimum inhibitory concentration (MIC) values were determined for 296 drug-resistant Gram-negative bacilli, and compared to previously determined plazomicin, amikacin, gentamicin, and tobramycin MIC values. Results: The MIC values required to inhibit 50% and 90% of isolates (MIC50 and MIC90, respectively) were 16 and >128 μg/ml, respectively. Conclusions: Arbekacin showed similar MIC50 values to amikacin and gentamicin, a lower MIC50 value than tobramycin, and a higher MIC50 value than plazomicin.

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