Magnetic Nanoparticles with Dual Surface Functions—Efficient Carriers for Metalloporphyrin-Catalyzed Drug Metabolite Synthesis in Batch and Continuous-Flow Reactors

Diána Balogh-Weiser; Balázs Decsi; Réka Krammer; Gergő Dargó; Ferenc Ender; János Mizsei; Róbert Berkecz; Benjámin Gyarmati; András Szilágyi; Róbert Tőtős; Csaba Paizs; László Poppe; György T. Balogh

doi:10.3390/nano10122329

Nanomaterials (Nov 2020)

Magnetic Nanoparticles with Dual Surface Functions—Efficient Carriers for Metalloporphyrin-Catalyzed Drug Metabolite Synthesis in Batch and Continuous-Flow Reactors

Diána Balogh-Weiser,
Balázs Decsi,
Réka Krammer,
Gergő Dargó,
Ferenc Ender,
János Mizsei,
Róbert Berkecz,
Benjámin Gyarmati,
András Szilágyi,
Róbert Tőtős,
Csaba Paizs,
László Poppe,
György T. Balogh

Affiliations

Diána Balogh-Weiser: Department of Organic Chemistry and Technology, Budapest University of Technology and Economics, Műegyetem rkp. 3, H-1111 Budapest, Hungary
Balázs Decsi: Department of Organic Chemistry and Technology, Budapest University of Technology and Economics, Műegyetem rkp. 3, H-1111 Budapest, Hungary
Réka Krammer: Department of Organic Chemistry and Technology, Budapest University of Technology and Economics, Műegyetem rkp. 3, H-1111 Budapest, Hungary
Gergő Dargó: Department of Chemical and Environmental Process Engineering, Budapest University of Technology and Economics, Műegyetem rkp. 3, H-1111 Budapest, Hungary
Ferenc Ender: Department of Electron Devices, Budapest University of Technology and Economics, Műegyetem rkp. 3, H-111 Budapest, Hungary
János Mizsei: Department of Electron Devices, Budapest University of Technology and Economics, Műegyetem rkp. 3, H-111 Budapest, Hungary
Róbert Berkecz: Institute of Pharmaceutical Analysis, Faculty of Pharmacy, University of Szeged, Somogyi utca 4., H-6720 Szeged, Hungary
Benjámin Gyarmati: Department of Physical Chemistry and Materials Science, Budapest University of Technology and Economics, Műegyetem rkp. 3, H-1111 Budapest, Hungary
András Szilágyi: Department of Physical Chemistry and Materials Science, Budapest University of Technology and Economics, Műegyetem rkp. 3, H-1111 Budapest, Hungary
Róbert Tőtős: Biocatalysis and Biotransformation Research Center, Faculty of Chemistry and Chemical Engineering, Babeş-Bolyai University of Cluj-Napoca, Arany János str. 11, 400028 Cluj-Napoca, Romania
Csaba Paizs: Biocatalysis and Biotransformation Research Center, Faculty of Chemistry and Chemical Engineering, Babeş-Bolyai University of Cluj-Napoca, Arany János str. 11, 400028 Cluj-Napoca, Romania
László Poppe: Department of Organic Chemistry and Technology, Budapest University of Technology and Economics, Műegyetem rkp. 3, H-1111 Budapest, Hungary
György T. Balogh: Department of Chemical and Environmental Process Engineering, Budapest University of Technology and Economics, Műegyetem rkp. 3, H-1111 Budapest, Hungary

DOI: https://doi.org/10.3390/nano10122329
Journal volume & issue: Vol. 10, no. 12
p. 2329

Abstract

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The dual functionalization of magnetic nanoparticles with inert (methyl) and reactive (aminopropyl) groups enables efficient immobilization of synthetic metalloporphyrins (such as 5,10,15,20-tetrakis(2,3,4,5,6-pentafluorophenyl)iron(II) porphyrin and 5,10,15,20-tetrakis-(4-sulfonatophenyl)iron(II) porphyrin) via covalent or ionic interactions. The proportion of reactive function on the surface has significant effect on the biomimetic activity of metalloporphyrins. The optimized magnetic nanocatalyst containing porphyrin was successfully applied for biomimetic oxidation of antihypertensive drug Amlodipine in batch and continuous-flow reactors as well.

Published in Nanomaterials

ISSN: 2079-4991 (Online)
Publisher: MDPI AG
Country of publisher: Switzerland
LCC subjects: Science: Chemistry
Website: https://www.mdpi.com/journal/nanomaterials

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