NADP+ is an endogenous PARP inhibitor in DNA damage response and tumor suppression

Chunjing Bian; Chao Zhang; Tao Luo; Aditi Vyas; Shih-Hsun Chen; Chao Liu; Muzaffer Ahmad Kassab; Ying Yang; Mei Kong; Xiaochun Yu

doi:10.1038/s41467-019-08530-5

Nature Communications (Feb 2019)

NADP+ is an endogenous PARP inhibitor in DNA damage response and tumor suppression

Chunjing Bian,
Chao Zhang,
Tao Luo,
Aditi Vyas,
Shih-Hsun Chen,
Chao Liu,
Muzaffer Ahmad Kassab,
Ying Yang,
Mei Kong,
Xiaochun Yu

Affiliations

Chunjing Bian: Department of Cancer Genetics and Epigenetics, Beckman Research Institute, City of Hope Medical Center
Chao Zhang: Department of General Surgery of Xuanwu Hospital, Capital Medical University
Tao Luo: Vascular Surgery Department of Xuanwu Hospital, Institute of Vascular Surgery, Capital Medical University
Aditi Vyas: Department of Cancer Genetics and Epigenetics, Beckman Research Institute, City of Hope Medical Center
Shih-Hsun Chen: Department of Cancer Genetics and Epigenetics, Beckman Research Institute, City of Hope Medical Center
Chao Liu: Department of Cancer Genetics and Epigenetics, Beckman Research Institute, City of Hope Medical Center
Muzaffer Ahmad Kassab: Department of Cancer Genetics and Epigenetics, Beckman Research Institute, City of Hope Medical Center
Ying Yang: Department of Cancer Biology, Beckman Research Institute, City of Hope Medical Center
Mei Kong: Department of Cancer Biology, Beckman Research Institute, City of Hope Medical Center
Xiaochun Yu: Department of Cancer Genetics and Epigenetics, Beckman Research Institute, City of Hope Medical Center

DOI: https://doi.org/10.1038/s41467-019-08530-5
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 14

Abstract

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Cancer cells respond differently to inhibitors of Poly (ADP-ribose) polymerase. Here the authors reveal that ovarian cancer cells with higher cellular NADP+ levels are more sensitive to clinically relevant PARP1 inhibitors and show that NADP+ act as an endogenous inhibitor of PARP enzymes.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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