Communications Biology (Jun 2021)
HTNV infection of CD8+ T cells is associated with disease progression in HFRS patients
- Rongrong Liu,
- Ruixue Ma,
- Ziyu Liu,
- Haifeng Hu,
- Jiayi Shu,
- Peizhen Hu,
- Junjun Kang,
- Yusi Zhang,
- Mingwei Han,
- Xiaoxiao Zhang,
- Yiting Zheng,
- Qikang Ying,
- Shiyuan Hou,
- Wenqiu Wang,
- Fang Wang,
- Ning Cheng,
- Yan Zhuang,
- Jianqi Lian,
- Xia Jin,
- Xingan Wu
Affiliations
- Rongrong Liu
- Department of Microbiology, School of Basic Medicine, Fourth Military Medical University
- Ruixue Ma
- Department of Microbiology, School of Basic Medicine, Fourth Military Medical University
- Ziyu Liu
- Department of Microbiology, School of Basic Medicine, Fourth Military Medical University
- Haifeng Hu
- Department of Infective Diseases, Tangdu Hospital, Fourth Military Medical University
- Jiayi Shu
- Shanghai Public Health Clinical Center, Fudan University
- Peizhen Hu
- State Key Laboratory of Cancer Biology, Department of Pathology, Xijing Hospital and School of Basic Medicine, Fourth Military Medical University
- Junjun Kang
- School of Basic Medicine, Fourth Military Medical University
- Yusi Zhang
- School of Basic Medicine, Fourth Military Medical University
- Mingwei Han
- School of Basic Medicine, Fourth Military Medical University
- Xiaoxiao Zhang
- Department of Microbiology, School of Basic Medicine, Fourth Military Medical University
- Yiting Zheng
- School of Basic Medicine, Fourth Military Medical University
- Qikang Ying
- Department of Microbiology, School of Basic Medicine, Fourth Military Medical University
- Shiyuan Hou
- Department of Microbiology, School of Basic Medicine, Fourth Military Medical University
- Wenqiu Wang
- School of Basic Medicine, Fourth Military Medical University
- Fang Wang
- Department of Microbiology, School of Basic Medicine, Fourth Military Medical University
- Ning Cheng
- Department of Otolaryngology-Head and Neck Surgery, University of California
- Yan Zhuang
- Department of Infective Diseases, Tangdu Hospital, Fourth Military Medical University
- Jianqi Lian
- Department of Infective Diseases, Tangdu Hospital, Fourth Military Medical University
- Xia Jin
- Shanghai Public Health Clinical Center, Fudan University
- Xingan Wu
- Department of Microbiology, School of Basic Medicine, Fourth Military Medical University
- DOI
- https://doi.org/10.1038/s42003-021-02182-2
- Journal volume & issue
-
Vol. 4,
no. 1
pp. 1 – 10
Abstract
Rongrong Liu et al. find that Hantaan virus, a common cause of hemorrhagic fever with renal syndrome (HFRS) in China, can infect CD8+ T cells and that these cells can support the full viral replication cycle. They also see an association between CD8+ T cells infection and disease progression in HFRS patients.
