Microbiologia Medica (Dec 2010)

Acute Hepatitis HCV genotype 3h: virological baseline characterization and monitoring “On Therapy”

  • Giuseppe Sodano,
  • Erasmo Falco,
  • Adriana Raddi,
  • Maria Grimaldi,
  • Francesco Labonia,
  • Marcello Raffone,
  • Mariano Bernardo,
  • Emanuele Durante Mangoni

DOI
https://doi.org/10.4081/mm.2010.2411
Journal volume & issue
Vol. 25, no. 4

Abstract

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The Hepatitis C viral genome is highly variable and is classified into 6 genotype groups, based on phylogenetic analysis of the genomic sequence. Here we show a case of acute Hepatitis C in which a rare genotype 3h was evidenced by direct RNA sequencing.We confirm that analysis of the early kinetics of HCV RNA during antiviral therapy is an important prognostic parameter, and that a (to-t3)log10HCV RNA value is a strong predictor for Rapid Virological Response (RVR) and End Therapy Response (ETR).

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