Hepatology Communications (Jan 2023)
A nationwide assessment of hepatocellular adenoma resection: Indications and pathological discordance
- Martijn P. D. Haring,
- Arthur K. E. Elfrink,
- Christiaan A. J. Oudmaijer,
- Paul C. M. Andel,
- Alicia Furumaya,
- Nenke de Jong,
- Colin J. J. M. Willems,
- Thijs Huits,
- Julie M. L. Sijmons,
- Eric J. T. Belt,
- Koop Bosscha,
- Esther C. J. Consten,
- Mariëlle M. E. Coolsen,
- Peter van Duijvendijk,
- Joris I. Erdmann,
- Paul Gobardhan,
- Robbert J. de Haas,
- Tjarda van Heek,
- Hwai‐Ding Lam,
- Wouter K. G. Leclercq,
- Mike S. L. Liem,
- Hendrik A. Marsman,
- Gijs A. Patijn,
- Türkan Terkivatan,
- Babs M. Zonderhuis,
- Izaak Quintus Molenaar,
- Wouter W. te Riele,
- Jeroen Hagendoorn,
- Alexander F. M. Schaapherder,
- Jan N. M. IJzermans,
- Carlijn I. Buis,
- Joost M. Klaase,
- Koert P. de Jong,
- Vincent E. de Meijer,
- ,
Affiliations
- Martijn P. D. Haring
- 1 Department of Surgery, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands
- Arthur K. E. Elfrink
- Christiaan A. J. Oudmaijer
- 4 Division of Hepatobiliary and Transplantation Surgery, Department of Surgery, Erasmus Medical Center Transplant Institute, Erasmus University Medical Center, Rotterdam, the Netherlands
- Paul C. M. Andel
- 5 Department of Surgery, Regional Academic Cancer Center Utrecht, Utrecht Medical Center Utrecht and St. Antonius Hospital Nieuwegein, University of Utrecht, Utrecht, the Netherlands
- Alicia Furumaya
- 6 Department of Surgery, Amsterdam Gastroenterology Endocrinology Metabolism, Amsterdam University Medical Center, University of Amsterdam, Amsterdam, the Netherlands
- Nenke de Jong
- 7 Department of Surgery, Medisch Spectrum Twente, Enschede, the Netherlands
- Colin J. J. M. Willems
- 8 Department of Surgery, Maastricht University Medical Center+, University of Maastricht, Maastricht, the Netherlands
- Thijs Huits
- 9 Department of Surgery, Onze Lieve Vrouwe Gasthuis, Amsterdam, the Netherlands
- Julie M. L. Sijmons
- 10 Department of Surgery, Máxima Medisch Centrum, Veldhoven, the Netherlands
- Eric J. T. Belt
- 11 Department of Surgery, Albert Sweitzer Ziekenhuis, Dordrecht, the Netherlands
- Koop Bosscha
- 12 Department of Surgery, Jeroen Bosch Ziekenhuis, ‘s‐Hertogenbosch, the Netherlands
- Esther C. J. Consten
- Mariëlle M. E. Coolsen
- 8 Department of Surgery, Maastricht University Medical Center+, University of Maastricht, Maastricht, the Netherlands
- Peter van Duijvendijk
- Joris I. Erdmann
- 6 Department of Surgery, Amsterdam Gastroenterology Endocrinology Metabolism, Amsterdam University Medical Center, University of Amsterdam, Amsterdam, the Netherlands
- Paul Gobardhan
- 16 Department of Surgery, Amphia Ziekenhuis, Breda, the Netherlands
- Robbert J. de Haas
- 17 Department of Radiology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands
- Tjarda van Heek
- 18 Department of Surgery, Ziekenhuis Gelderse Vallei, Ede, the Netherlands
- Hwai‐Ding Lam
- 19 Department of Surgery, Leiden University Medical Center, University of Leiden, Leiden, the Netherlands
- Wouter K. G. Leclercq
- 10 Department of Surgery, Máxima Medisch Centrum, Veldhoven, the Netherlands
- Mike S. L. Liem
- 7 Department of Surgery, Medisch Spectrum Twente, Enschede, the Netherlands
- Hendrik A. Marsman
- 9 Department of Surgery, Onze Lieve Vrouwe Gasthuis, Amsterdam, the Netherlands
- Gijs A. Patijn
- 15 Department of Surgery, Isala Klinieken, Zwolle, the Netherlands
- Türkan Terkivatan
- 4 Division of Hepatobiliary and Transplantation Surgery, Department of Surgery, Erasmus Medical Center Transplant Institute, Erasmus University Medical Center, Rotterdam, the Netherlands
- Babs M. Zonderhuis
- 20 Department of Surgery, Amsterdam Gastroenterology Endocrinology Metabolism, Amsterdam University Medical Center, Vrije Universiteit, Amsterdam, the Netherlands
- Izaak Quintus Molenaar
- 5 Department of Surgery, Regional Academic Cancer Center Utrecht, Utrecht Medical Center Utrecht and St. Antonius Hospital Nieuwegein, University of Utrecht, Utrecht, the Netherlands
- Wouter W. te Riele
- 5 Department of Surgery, Regional Academic Cancer Center Utrecht, Utrecht Medical Center Utrecht and St. Antonius Hospital Nieuwegein, University of Utrecht, Utrecht, the Netherlands
- Jeroen Hagendoorn
- 5 Department of Surgery, Regional Academic Cancer Center Utrecht, Utrecht Medical Center Utrecht and St. Antonius Hospital Nieuwegein, University of Utrecht, Utrecht, the Netherlands
- Alexander F. M. Schaapherder
- 19 Department of Surgery, Leiden University Medical Center, University of Leiden, Leiden, the Netherlands
- Jan N. M. IJzermans
- 4 Division of Hepatobiliary and Transplantation Surgery, Department of Surgery, Erasmus Medical Center Transplant Institute, Erasmus University Medical Center, Rotterdam, the Netherlands
- Carlijn I. Buis
- 1 Department of Surgery, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands
- Joost M. Klaase
- 1 Department of Surgery, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands
- Koert P. de Jong
- 1 Department of Surgery, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands
- Vincent E. de Meijer
- 1 Department of Surgery, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands
- DOI
- https://doi.org/10.1002/hep4.2110
- Journal volume & issue
-
Vol. 7,
no. 1
pp. e2110 – e2110
Abstract
Hepatocellular adenomas (HCAs) are benign liver tumors associated with bleeding or malignant transformation. Data on the indication for surgery are scarce. We analyzed indications and outcome of patients operated for HCAs 50 mm (52%), suspicion of (pre)malignancy (28%), and (previous) bleeding (5.1%). No difference was observed in HCA‐subtype distribution between small and large tumors. Ninety‐six (43%) patients had a postoperative change in diagnosis. Independent risk factors for change in diagnosis were tumor size <50 mm (adjusted odds ratio [aOR], 3.4; p < 0.01), male sex (aOR, 3.7; p = 0.03), and lack of hepatobiliary contrast‐enhanced magnetic resonance imaging (CE‐MRI) (aOR, 1.8; p = 0.04). Resection for small (suspected) HCAs was mainly indicated by suspicion of (pre)malignancy, whereas for large (suspected) HCAs, tumor size was the most prevalent indication. Male sex, tumor size <50 mm, and lack of hepatobiliary CE‐MRI were independent risk factors for postoperative change in tumor diagnosis.
