Altered regulation of mesenchymal cell senescence in adipose tissue promotes pathological changes associated with diabetic wound healing

Arisa Kita; Yuki Saito; Norihiro Miura; Maki Miyajima; Sena Yamamoto; Tsukasa Sato; Takatoshi Yotsuyanagi; Mineko Fujimiya; Takako S. Chikenji

doi:10.1038/s42003-022-03266-3

Communications Biology (Apr 2022)

Altered regulation of mesenchymal cell senescence in adipose tissue promotes pathological changes associated with diabetic wound healing

Arisa Kita,
Yuki Saito,
Norihiro Miura,
Maki Miyajima,
Sena Yamamoto,
Tsukasa Sato,
Takatoshi Yotsuyanagi,
Mineko Fujimiya,
Takako S. Chikenji

Affiliations

Arisa Kita: Department of Plastic and Reconstructive Surgery, Sapporo Medical University
Yuki Saito: Department of Anatomy, Sapporo Medical University School of Medicine
Norihiro Miura: Graduate School of Health Sciences, Hokkaido University
Maki Miyajima: Graduate School of Health Sciences, Hokkaido University
Sena Yamamoto: Graduate School of Health Sciences, Hokkaido University
Tsukasa Sato: Graduate School of Health Sciences, Hokkaido University
Takatoshi Yotsuyanagi: Department of Plastic and Reconstructive Surgery, Sapporo Medical University
Mineko Fujimiya: Department of Anatomy, Sapporo Medical University School of Medicine
Takako S. Chikenji: Department of Anatomy, Sapporo Medical University School of Medicine

DOI: https://doi.org/10.1038/s42003-022-03266-3
Journal volume & issue: Vol. 5, no. 1
pp. 1 – 16

Abstract

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Type-2 diabetic adipose tissue impairs transient senescence during wound healing with expression of different components of the senescence-associated secretory phenotype (SASP), and this is associated with deteriorated wound healing.

Published in Communications Biology

ISSN: 2399-3642 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General)
Website: https://www.nature.com/commsbio/

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