Inhibition of Brain Area and Functional Connectivity in Idiopathic Sudden Sensorineural Hearing Loss With Tinnitus, Based on Resting-State EEG

Yuexin Cai; Yuexin Cai; Jiahong Li; Jiahong Li; Yanhong Chen; Yanhong Chen; Wan Chen; Caiping Dang; Caiping Dang; Fei Zhao; Fei Zhao; Wenrui Li; Wenrui Li; Guisheng Chen; Guisheng Chen; Suijun Chen; Suijun Chen; Maojin Liang; Maojin Liang; Yiqing Zheng; Yiqing Zheng

doi:10.3389/fnins.2019.00851

Frontiers in Neuroscience (Aug 2019)

Inhibition of Brain Area and Functional Connectivity in Idiopathic Sudden Sensorineural Hearing Loss With Tinnitus, Based on Resting-State EEG

Yuexin Cai,
Yuexin Cai,
Jiahong Li,
Jiahong Li,
Yanhong Chen,
Yanhong Chen,
Wan Chen,
Caiping Dang,
Caiping Dang,
Fei Zhao,
Fei Zhao,
Wenrui Li,
Wenrui Li,
Guisheng Chen,
Guisheng Chen,
Suijun Chen,
Suijun Chen,
Maojin Liang,
Maojin Liang,
Yiqing Zheng,
Yiqing Zheng

Affiliations

Yuexin Cai: Department of Otolaryngology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China
Yuexin Cai: Institute of Hearing and Speech-Language Science, Sun Yat-sen University, Guangzhou, China
Jiahong Li: Department of Otolaryngology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China
Jiahong Li: Institute of Hearing and Speech-Language Science, Sun Yat-sen University, Guangzhou, China
Yanhong Chen: Department of Otolaryngology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China
Yanhong Chen: Institute of Hearing and Speech-Language Science, Sun Yat-sen University, Guangzhou, China
Wan Chen: State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, China
Caiping Dang: Affiliated Brain Hospital of Guangzhou Medical University, Guangzhou, China
Caiping Dang: Department of Psychology, Guangzhou Medical University, Guangzhou, China
Fei Zhao: Department of Speech Language Therapy and Hearing Science, Cardiff Metropolitan University, Cardiff, United Kingdom
Fei Zhao: Department of Hearing and Speech Science, Xinhua College, Sun Yat-sen University, Guangzhou, China
Wenrui Li: Department of Otolaryngology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China
Wenrui Li: Institute of Hearing and Speech-Language Science, Sun Yat-sen University, Guangzhou, China
Guisheng Chen: Department of Otolaryngology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China
Guisheng Chen: Institute of Hearing and Speech-Language Science, Sun Yat-sen University, Guangzhou, China
Suijun Chen: Department of Otolaryngology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China
Suijun Chen: Institute of Hearing and Speech-Language Science, Sun Yat-sen University, Guangzhou, China
Maojin Liang: Department of Otolaryngology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China
Maojin Liang: Institute of Hearing and Speech-Language Science, Sun Yat-sen University, Guangzhou, China
Yiqing Zheng: Department of Otolaryngology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China
Yiqing Zheng: Institute of Hearing and Speech-Language Science, Sun Yat-sen University, Guangzhou, China

DOI: https://doi.org/10.3389/fnins.2019.00851
Journal volume & issue: Vol. 13

Abstract

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This study aimed to identify the mechanism behind idiopathic sudden sensorineural hearing loss (ISSNHL) in patients with tinnitus by investigating aberrant activity in areas of the brain and functional connectivity. High-density electroencephalography (EEG) was used to investigate central nervous changes in 25 ISSNHL subjects and 27 healthy controls. ISSNHL subjects had significantly reduced activity in the left frontal lobe at the alpha 2 frequency band compared with controls. Linear lagged connectivity and lagged coherence analysis showed significantly reduced functional connectivity between the temporal gyrus and supramarginal gyrus at the gamma 2 frequency band in the ISSNHL group. Additionally, a significantly reduced functional connectivity was found between the central cingulate gyrus and frontal lobe under lagged phase synchronization analysis. These results strongly indicate inhibition of brain area activity and change in functional connectivity in ISSNHL with tinnitus patients.

Published in Frontiers in Neuroscience

ISSN: 1662-4548 (Print); 1662-453X (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Medicine: Internal medicine: Neurosciences. Biological psychiatry. Neuropsychiatry
Website: http://www.frontiersin.org/neuroscience

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