Increased adiposity-to-muscle ratio and severity of sinusitis affect quality of life in asthma: Computed tomographic analysis

Kaoruko Shimizu, MD, PhD; Hirokazu Kimura, MD, PhD; Naoya Tanabe, MD, PhD; Kazuya Tanimura, MD, PhD; Shotaro Chubachi, MD, PhD; Hiroaki Iijima, MD, PhD; Susumu Sato, MD, PhD; Nobuyasu Wakazono, MD; Yuji Nakamaru, MD, PhD; Kazufumi Okada, PhD; Hironi Makita, MD, PhD; Houman Goudarzi, MD, PhD; Masaru Suzuki, MD, PhD; Masaharu Nishimura, MD, PhD; Satoshi Konno, MD, PhD

Journal of Allergy and Clinical Immunology: Global (Aug 2024)

Increased adiposity-to-muscle ratio and severity of sinusitis affect quality of life in asthma: Computed tomographic analysis

Kaoruko Shimizu, MD, PhD,
Hirokazu Kimura, MD, PhD,
Naoya Tanabe, MD, PhD,
Kazuya Tanimura, MD, PhD,
Shotaro Chubachi, MD, PhD,
Hiroaki Iijima, MD, PhD,
Susumu Sato, MD, PhD,
Nobuyasu Wakazono, MD,
Yuji Nakamaru, MD, PhD,
Kazufumi Okada, PhD,
Hironi Makita, MD, PhD,
Houman Goudarzi, MD, PhD,
Masaru Suzuki, MD, PhD,
Masaharu Nishimura, MD, PhD,
Satoshi Konno, MD, PhD

Affiliations

Kaoruko Shimizu, MD, PhD: Division of Emergent Respiratory and Cardiovascular Medicine, Hokkaido University Hospital, Sapporo, Japan; Department of Respiratory Medicine, Faculty of Medicine, Hokkaido University, Sapporo, Japan; Corresponding author: Kaoruko Shimizu, MD, PhD, Division of Emergent Respiratory and Cardiovascular Medicine, Hokkaido University Hospital, North 15 West 7, Kita-ku, Sapporo 060-8638, Japan.
Hirokazu Kimura, MD, PhD: Department of Respiratory Medicine, Faculty of Medicine, Hokkaido University, Sapporo, Japan
Naoya Tanabe, MD, PhD: Department of Respiratory Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan
Kazuya Tanimura, MD, PhD: Department of Respiratory Medicine, Nara Medical University, Kashihara, Japan
Shotaro Chubachi, MD, PhD: Department of Medicine, Division of Pulmonary Medicine, Keio University School of Medicine, Tokyo, Japan
Hiroaki Iijima, MD, PhD: Department of Respiratory Medicine, Tsukuba Medical Center Hospital, Tsukuba, Japan
Susumu Sato, MD, PhD: Department of Respiratory Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan
Nobuyasu Wakazono, MD: Department of Respiratory Medicine, Faculty of Medicine, Hokkaido University, Sapporo, Japan
Yuji Nakamaru, MD, PhD: Department of Otolaryngology–Head and Neck Surgery, School of Medicine, Hokkaido University, Sapporo, Japan
Kazufumi Okada, PhD: Data Science Center, Promotion Unit, Institute of Health Science Innovation for Medical Care, Hokkaido University Hospital, Sapporo, Japan
Hironi Makita, MD, PhD: Department of Respiratory Medicine, Faculty of Medicine, Hokkaido University, Sapporo, Japan; Hokkaido Medical Research Institute for Respiratory Diseases, Sapporo, Japan
Houman Goudarzi, MD, PhD: Department of Respiratory Medicine, Faculty of Medicine, Hokkaido University, Sapporo, Japan
Masaru Suzuki, MD, PhD: Department of Respiratory Medicine, Faculty of Medicine, Hokkaido University, Sapporo, Japan
Masaharu Nishimura, MD, PhD: Department of Respiratory Medicine, Faculty of Medicine, Hokkaido University, Sapporo, Japan; Hokkaido Medical Research Institute for Respiratory Diseases, Sapporo, Japan
Satoshi Konno, MD, PhD: Department of Respiratory Medicine, Faculty of Medicine, Hokkaido University, Sapporo, Japan

Journal volume & issue: Vol. 3, no. 3
p. 100277

Abstract

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Background: Deteriorated sinusitis and increased adiposity relative to muscle mass may affect quality of life in patients with asthma. However, whether these effects are observed regardless of intrapulmonary pathology is unknown. Objectives: We evaluated the correlation of the cross-sectional ratio of abdominal visceral fat (VF) to erector spinae muscle (ESM) and sinus findings based on Lund-Mackey scoring system (LMS) on computed tomography (CT) with the impaired score of the Asthma Quality of Life Questionnaire (AQLQ), regardless of airway and parenchymal disease, in patients with asthma. Methods: We recruited participants from the Hokkaido-based severe asthma cohort who had completed AQLQ and CT examination at the entry. The participants were divided into high (highest) and low (other quartiles) groups on the bases of the extrapulmonary indices. Multivariate analysis examined the association of VF/ESM for the adiposity-to-muscle ratio and LMS with AQLQ after adjusting for the airway fractal dimension for airway index and percentage of low attenuation volume to lung volume for parenchymal index. Results: No significant differences were observed in VF/ESM and LMS in terms of sex. The AQLQ score in the high VF/ESM group and high LMS group was lower than those in low VF/ESM group and low LMS group (63 male and 100 female subjects). High VF/ESM (estimate [95% confidence interval] (−0.43 [−0.61, −0.25]) and high LMS scores (−0.22 [−0.41, −0.03]) were associated with low AQLQ scores when adjusted for age, body mass index, smoking status, blood eosinophil count, and intrapulmonary CT indices. Conclusions: Increased VF relative to ESM mass and high LMS may deteriorate asthma-related quality of life, regardless of presence of intrapulmonary disease.

Published in Journal of Allergy and Clinical Immunology: Global

ISSN: 2772-8293 (Online)
Publisher: Elsevier
Country of publisher: United States
LCC subjects: Medicine: Internal medicine: Specialties of internal medicine: Immunologic diseases. Allergy
Website: https://www.sciencedirect.com/journal/journal-of-allergy-and-clinical-immunology-global

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