Experimental Studies of the Effect of Cyclic Mitoguazone Analogues on Antineoplastic Activity of Methotrexate

Abstract

In the presented study we tested the effect of the bi- and monocyclic analogues of mitoguazone on neoplastic activity of methotrexate in the model of L1210 leukemia in mice. We have demonstrated that combined therapy involving administration of methotrexate with 2-oxo-propanal bis (4,5,6,7 -tetrahydroIH- l,3-diazepin-2-yl)methylhydrazone dihydroiodide (aM 7) at different doses is more effective than methotrexate monotherapy in mice inoculated with L1210 leukemia.

Keywords

• methotrexate (mtx)
• mitoguazone analogues (am)
• interaction
• l1210 mouse leukemia