Nature Communications (Oct 2020)
T cell-intrinsic role for Nod2 in protection against Th17-mediated uveitis
- Ruth J. Napier,
- Ellen J. Lee,
- Michael P. Davey,
- Emily E. Vance,
- João M. Furtado,
- Paige E. Snow,
- Kimberly A. Samson,
- Sydney J. Lashley,
- Brieanna R. Brown,
- Reiko Horai,
- Mary J. Mattapallil,
- Biying Xu,
- Michelle C. Callegan,
- Luke S. Uebelhoer,
- Christina L. Lancioni,
- Richard K. Vehe,
- Bryce A. Binstadt,
- Justine R. Smith,
- Rachel R. Caspi,
- Holly L. Rosenzweig
Affiliations
- Ruth J. Napier
- VA Portland Health Care System
- Ellen J. Lee
- VA Portland Health Care System
- Michael P. Davey
- VA Portland Health Care System
- Emily E. Vance
- VA Portland Health Care System
- João M. Furtado
- Division of Ophthalmology, Ribeirão Preto Medical School, University of São Paulo
- Paige E. Snow
- Department of Public Health, Oregon Health and Science University
- Kimberly A. Samson
- Providence Cancer Institute
- Sydney J. Lashley
- VA Portland Health Care System
- Brieanna R. Brown
- Providence Medical Group
- Reiko Horai
- Laboratory of Immunology, NEI, NIH
- Mary J. Mattapallil
- Laboratory of Immunology, NEI, NIH
- Biying Xu
- Laboratory of Immunology, NEI, NIH
- Michelle C. Callegan
- Department of Ophthalmology, University of Oklahoma Health Sciences Center
- Luke S. Uebelhoer
- Department of Pediatrics, Oregon Health and Science University
- Christina L. Lancioni
- Department of Pediatrics, Oregon Health and Science University
- Richard K. Vehe
- Department of Pediatrics, University of Minnesota and the University of Minnesota Masonic Children’s Hospital
- Bryce A. Binstadt
- Department of Pediatrics, University of Minnesota and the University of Minnesota Masonic Children’s Hospital
- Justine R. Smith
- College of Medicine and Public Health, Flinders University
- Rachel R. Caspi
- Laboratory of Immunology, NEI, NIH
- Holly L. Rosenzweig
- VA Portland Health Care System
- DOI
- https://doi.org/10.1038/s41467-020-18961-0
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 16
Abstract
How mutations in the microbial receptor NOD2 induce Blau syndrome in humans and related uveitis is unclear. Here the authors show, using Nod2-deficient mice and experimental uveitis, that Nod2 negatively regulates T cell activation and transcription of autoimmunity-related genes to suppress Th17 responses and uveitis.
