Frontiers in Oncology (Feb 2022)

Use of Pralsetinib as Neoadjuvant Therapy for Non-Small Cell Lung Cancer Patient With RET Rearrangement

  • Ning Zhou,
  • Ning Zhou,
  • Tong Li,
  • Tong Li,
  • Maoli Liang,
  • Fan Ren,
  • Fan Ren,
  • Hong Ni,
  • Hong Ni,
  • Wei Liu,
  • Tao Shi,
  • Dongbo Xu,
  • Qiusong Chen,
  • Haonan Yu,
  • Zuoqing Song,
  • Zuoqing Song,
  • Lingling Zu,
  • Lingling Zu,
  • Shuo Li,
  • Song Xu,
  • Song Xu

DOI
https://doi.org/10.3389/fonc.2022.848779
Journal volume & issue
Vol. 12

Abstract

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RET rearrangements are rare, and occur in 1%-2% of all non-small cell lung cancer (NSCLC) patients. Pralsetinib has a significant anti-tumor effect in patients with advanced NSCLC and a RET rearrangement. Previous studies have confirmed the efficiency of neoadjuvant target therapy for NSCLC. Herein we present a case involving a female patient who was diagnosed with stage IIIA lung adenocarcinoma and harbored a KIF5B-RET rearrangement based on next-generation sequencing. Radiologic downstaging was indicated after pralsetinib treatment. Therefore, a right lower lobectomy and systemic lymphadenectomy were successfully performed. The postoperative pathologic results revealed a response rate of 74% for primary tumor and no residual viable tumor cells were observed in lymph nodes. The tumor, nodes, and metastases (TNM) stage was ypT1cN1M0. The tumor micro-environment (TME) of the primary tumor was also assessed.

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