Frontiers in Pharmacology (Feb 2023)

Chemo-free maintenance therapy in adult T-cell acute lymphoblastic leukemia: A case report and literature review

  • Yuanbin Song,
  • Shuzhao Chen,
  • Chenfei Liu,
  • Lezong Chen,
  • Weida Wang,
  • Bingyi Wu,
  • Yang Liang

DOI
https://doi.org/10.3389/fphar.2023.1051305
Journal volume & issue
Vol. 14

Abstract

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Maintenance therapy in adult T-cell acute lymphoblastic leukemia (T-ALL) is the longest phase but with limited option. The classic drugs used in the maintenance phase such as 6-mercaptopurine, methotrexate, corticosteroid and vincristine have potentially serious toxicities. Optimizing therapy in the modern age, chemo-free maintenance therapy regimens for patients with T-ALL may dramatically improve the maintenance therapeutic landscape. We report here the combination of Anti-programmed cell death protein 1 antibody and histone deacetylase inhibitor as chemo-free maintenance treatment in a T-ALL patient with literature review, thus providing a unique perspective in addition to valuable information which may inform novel therapeutic approaches.

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