Hydrothermal synthesis of pure and bio modified TiO2: Characterization, evaluation of antibacterial activity against gram positive and gram negative bacteria and anticancer activity against KB Oral cancer cell line

Abstract

Titanium dioxide nanoparticles were found to be good anticancer and antibacterial agents. In this study, the antibacterial and anticancer activities of pure TiO2, turmeric, ginger and garlic modified TiO2 nanoparticles were investigated. X-ray diffraction (XRD), Transmission electron microscopy (TEM), Fourier transform infrared spectroscopy (FTIR) and UV–visible spectroscopy were used to analyze the samples. Antibacterial activities were performed against five bacterial strains namely Escherichia coli, Klebsiella pneumonia, Pseudomonas aeruoginosa, Staphylococcus aureus and Streptococcus mutans. The modified TiO2 nanoparticles exhibited enhanced antibacterial activity when compared with pure TiO2 samples and anticancer activities for the samples were performed in KB Oral cancer cell line. The results of the modified TiO2 NPs indicate a greater efficacy on anticancer and antibacterial properties compared to the pure TiO2 NPs. Keywords: TiO2 nanoparticles, XRD, TEM, Antibacterial, Anticancer, Ginger, Garlic and turmeric