Stem cells as potential therapeutics for hearing loss

Qiaojun Fang; Qiaojun Fang; Yongjie Wei; Yuhua Zhang; Wei Cao; Lin Yan; Mengdie Kong; Yongjun Zhu; Yan Xu; Lingna Guo; Lei Zhang; Weiqing Wang; Yafeng Yu; Jingwu Sun; Jianming Yang

doi:10.3389/fnins.2023.1259889

Frontiers in Neuroscience (Sep 2023)

Stem cells as potential therapeutics for hearing loss

Qiaojun Fang,
Qiaojun Fang,
Yongjie Wei,
Yuhua Zhang,
Wei Cao,
Lin Yan,
Mengdie Kong,
Yongjun Zhu,
Yan Xu,
Lingna Guo,
Lei Zhang,
Weiqing Wang,
Yafeng Yu,
Jingwu Sun,
Jianming Yang

Affiliations

Qiaojun Fang: Department of Otolaryngology-Head and Neck Surgery, the Second Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China
Qiaojun Fang: School of Life Sciences and Technology, Southeast University, Nanjing, China
Yongjie Wei: Department of Otolaryngology-Head and Neck Surgery, the Second Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China
Yuhua Zhang: Department of Otolaryngology-Head and Neck Surgery, the Second Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China
Wei Cao: Department of Otolaryngology-Head and Neck Surgery, the Second Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China
Lin Yan: Department of Otolaryngology-Head and Neck Surgery, the Second Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China
Mengdie Kong: School of Life Sciences and Technology, Southeast University, Nanjing, China
Yongjun Zhu: Department of Otolaryngology-Head and Neck Surgery, the Second Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China
Yan Xu: Department of Otolaryngology-Head and Neck Surgery, the Second Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China
Lingna Guo: Department of Otolaryngology-Head and Neck Surgery, the Second Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China
Lei Zhang: Department of Otolaryngology-Head and Neck Surgery, the Second Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China
Weiqing Wang: Department of Otolaryngology-Head and Neck Surgery, the Second Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China
Yafeng Yu: Department of Otolaryngology-Head and Neck Surgery, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China
Jingwu Sun: Department of Otolaryngology-Head and Neck Surgery, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui, China
Jianming Yang: Department of Otolaryngology-Head and Neck Surgery, the Second Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China

DOI: https://doi.org/10.3389/fnins.2023.1259889
Journal volume & issue: Vol. 17

Abstract

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Hearing impairment is a global health problem. Stem cell therapy has become a cutting-edge approach to tissue regeneration. In this review, the recent advances in stem cell therapy for hearing loss have been discussed. Nanomaterials can modulate the stem cell microenvironment to augment the therapeutic effects further. The potential of combining nanomaterials with stem cells for repairing and regenerating damaged inner ear hair cells (HCs) and spiral ganglion neurons (SGNs) has also been discussed. Stem cell-derived exosomes can contribute to the repair and regeneration of damaged tissue, and the research progress on exosome-based hearing loss treatment has been summarized as well. Despite stem cell therapy’s technical and practical limitations, the findings reported so far are promising and warrant further investigation for eventual clinical translation.

Published in Frontiers in Neuroscience

ISSN: 1662-4548 (Print); 1662-453X (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Medicine: Internal medicine: Neurosciences. Biological psychiatry. Neuropsychiatry
Website: http://www.frontiersin.org/neuroscience

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