Neuropathological correlates and genetic architecture of microglial activation in elderly human brain

Daniel Felsky; Tina Roostaei; Kwangsik Nho; Shannon L. Risacher; Elizabeth M. Bradshaw; Vlad Petyuk; Julie A. Schneider; Andrew Saykin; David A. Bennett; Philip L. De Jager

doi:10.1038/s41467-018-08279-3

Nature Communications (Jan 2019)

Neuropathological correlates and genetic architecture of microglial activation in elderly human brain

Daniel Felsky,
Tina Roostaei,
Kwangsik Nho,
Shannon L. Risacher,
Elizabeth M. Bradshaw,
Vlad Petyuk,
Julie A. Schneider,
Andrew Saykin,
David A. Bennett,
Philip L. De Jager

Affiliations

Daniel Felsky: Center for Translational and Computational Neuroimmunology, Department of Neurology, Columbia University Medical Center
Tina Roostaei: Center for Translational and Computational Neuroimmunology, Department of Neurology, Columbia University Medical Center
Kwangsik Nho: Indiana Alzheimer’s Disease Center, Center for Neuroimaging, Department of Radiology and Imaging Sciences, Center for Computational Biology and Bioinformatics, Indiana University School of Medicine
Shannon L. Risacher: Indiana Alzheimer’s Disease Center, Center for Neuroimaging, Department of Radiology and Imaging Sciences, Center for Computational Biology and Bioinformatics, Indiana University School of Medicine
Elizabeth M. Bradshaw: Center for Translational and Computational Neuroimmunology, Department of Neurology, Columbia University Medical Center
Vlad Petyuk: Pacific Northwest National Laboratory
Julie A. Schneider: Department of Neurology, Rush University Medical Center
Andrew Saykin: Indiana Alzheimer’s Disease Center, Center for Neuroimaging, Department of Radiology and Imaging Sciences, Center for Computational Biology and Bioinformatics, Indiana University School of Medicine
David A. Bennett: Department of Neurology, Rush University Medical Center
Philip L. De Jager: Center for Translational and Computational Neuroimmunology, Department of Neurology, Columbia University Medical Center

DOI: https://doi.org/10.1038/s41467-018-08279-3
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 12

Abstract

Read online

The consequences of microglial activation in the aging human brain remain unknown. This study quantified microglial morphology and density in the elderly human brain to show that cortical microglial activation strongly associates with AD pathogenesis and may be an upstream contributor to cognitive decline via the accumulation of tau pathology.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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