Nature Communications (Nov 2018)
Adipocyte-secreted BMP8b mediates adrenergic-induced remodeling of the neuro-vascular network in adipose tissue
- Vanessa Pellegrinelli,
- Vivian J. Peirce,
- Laura Howard,
- Samuel Virtue,
- Dénes Türei,
- Martina Senzacqua,
- Andrea Frontini,
- Jeffrey W. Dalley,
- Antony R. Horton,
- Guillaume Bidault,
- Ilenia Severi,
- Andrew Whittle,
- Kamal Rahmouni,
- Julio Saez-Rodriguez,
- Saverio Cinti,
- Alun M. Davies,
- Antonio Vidal-Puig
Affiliations
- Vanessa Pellegrinelli
- Metabolic Research Laboratories, Institute of Metabolic Science, Addenbrooke’s Hospital, University of Cambridge
- Vivian J. Peirce
- Metabolic Research Laboratories, Institute of Metabolic Science, Addenbrooke’s Hospital, University of Cambridge
- Laura Howard
- School of Biosciences, Cardiff University
- Samuel Virtue
- Metabolic Research Laboratories, Institute of Metabolic Science, Addenbrooke’s Hospital, University of Cambridge
- Dénes Türei
- European Molecular Biology Laboratory (EMBL), Structural and Computational Biology Unit
- Martina Senzacqua
- Department of Experimental and Clinical Medicine, Center of Obesity, Università Politecnica delle Marche
- Andrea Frontini
- Department of Public Health, Experimental and Forensic Medicine, University of Pavia
- Jeffrey W. Dalley
- Department of Psychology, University of Cambridge
- Antony R. Horton
- School of Biosciences, Cardiff University
- Guillaume Bidault
- Metabolic Research Laboratories, Institute of Metabolic Science, Addenbrooke’s Hospital, University of Cambridge
- Ilenia Severi
- Department of Experimental and Clinical Medicine, Center of Obesity, Università Politecnica delle Marche
- Andrew Whittle
- Metabolic Research Laboratories, Institute of Metabolic Science, Addenbrooke’s Hospital, University of Cambridge
- Kamal Rahmouni
- Department of Pharmacology, University of Iowa
- Julio Saez-Rodriguez
- European Molecular Biology Laboratory (EMBL), European Bioinformatics Institute (EBI)
- Saverio Cinti
- Department of Experimental and Clinical Medicine, Center of Obesity, Università Politecnica delle Marche
- Alun M. Davies
- School of Biosciences, Cardiff University
- Antonio Vidal-Puig
- Metabolic Research Laboratories, Institute of Metabolic Science, Addenbrooke’s Hospital, University of Cambridge
- DOI
- https://doi.org/10.1038/s41467-018-07453-x
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 18
Abstract
Enhancing thermogenesis is a promising therapeutic strategy for promoting metabolic health. Here the authors show that adipocyte-secreted BMP8b contributes to optimizing the thermogenic response by remodeling of the neuro-vascular networks in brown and white adipose tissue.
