International Journal of Clinical Practice (Jan 2023)
Epidemiology and Association Rules Analysis for Pulmonary Tuberculosis Cases with Extrapulmonary Tuberculosis from Age and Gender Perspective: A Large-Scale Retrospective Multicenter Observational Study in China
- Wanli Kang,
- Jiajia Yu,
- Chen Liang,
- Quanhong Wang,
- Liang Li,
- Jian Du,
- Hongyan Chen,
- Jianxiong Liu,
- Jinshan Ma,
- Mingwu Li,
- Jingmin Qin,
- Wei Shu,
- Peilan Zong,
- Yi Zhang,
- Xiaofeng Yan,
- Zhiyi Yang,
- Zaoxian Mei,
- Qunyi Deng,
- Pu Wang,
- Wenge Han,
- Meiying Wu,
- Ling Chen,
- Xinguo Zhao,
- Lei Tan,
- Fujian Li,
- Chao Zheng,
- Hongwei Liu,
- Xinjie Li,
- Ertai A.,
- Yingrong Du,
- Fenglin Liu,
- Wenyu Cui,
- Song Yang,
- Xiaohong Chen,
- Junfeng Han,
- Qingyao Xie,
- Yanmei Feng,
- Wenyu Liu,
- Peijun Tang,
- Jianyong Zhang,
- Jian Zheng,
- Dawei Chen,
- Xiangyang Yao,
- Tong Ren,
- Yan Li,
- Yuanyuan Li,
- Lei Wu,
- Qiang Song,
- Mei Yang,
- Jian Zhang,
- Yuanyuan Liu,
- Shuliang Guo,
- Kun Yan,
- Xinghua Shen,
- Dan Lei,
- Yanli Zhang,
- Youcai Li,
- Yongkang Dong,
- Shenjie Tang
Affiliations
- Wanli Kang
- Beijing Chest Hospital
- Jiajia Yu
- Beijing Chest Hospital
- Chen Liang
- Beijing Chest Hospital
- Quanhong Wang
- Taiyuan Fourth People’s Hospital
- Liang Li
- Beijing Chest Hospital
- Jian Du
- Beijing Chest Hospital
- Hongyan Chen
- Shenyang Chest Hospital
- Jianxiong Liu
- Guang Zhou Chest Hospital
- Jinshan Ma
- Chest Hospital of Xinjiang
- Mingwu Li
- The Third People’s Hospital of Kunming
- Jingmin Qin
- Shandong Provincial Chest Hospital
- Wei Shu
- Beijing Chest Hospital
- Peilan Zong
- Jiangxi Chest (Third People) Hospital
- Yi Zhang
- Chang Chun Infectious Diseases Hospital
- Xiaofeng Yan
- Chongqing Public Health Medical Center
- Zhiyi Yang
- Fuzhou Pulmonary Hospital of Fujian
- Zaoxian Mei
- Tianjin Haihe Hospital
- Qunyi Deng
- Third People’s Hospital of Shenzhen
- Pu Wang
- The First Affiliated Hospital of Chongqing Medical University
- Wenge Han
- Weifang No. 2 People’s Hospital
- Meiying Wu
- The Fifth People’s Hospital of Suzhou
- Ling Chen
- Affiliated Hospital of Zunyi Medical College
- Xinguo Zhao
- The Fifth People’s Hospital of Wuxi
- Lei Tan
- TB Hospital of Siping City
- Fujian Li
- Baoding Hospital for Infectious Disease
- Chao Zheng
- The First Affiliated of XiaMen University
- Hongwei Liu
- Shenyang Chest Hospital
- Xinjie Li
- Guang Zhou Chest Hospital
- Ertai A.
- Chest Hospital of Xinjiang
- Yingrong Du
- The Third People’s Hospital of Kunming
- Fenglin Liu
- Shandong Provincial Chest Hospital
- Wenyu Cui
- Chang Chun Infectious Diseases Hospital
- Song Yang
- Chongqing Public Health Medical Center
- Xiaohong Chen
- Fuzhou Pulmonary Hospital of Fujian
- Junfeng Han
- Tianjin Haihe Hospital
- Qingyao Xie
- Third People’s Hospital of Shenzhen
- Yanmei Feng
- The First Affiliated Hospital of Chongqing Medical University
- Wenyu Liu
- Weifang No. 2 People’s Hospital
- Peijun Tang
- The Fifth People’s Hospital of Suzhou
- Jianyong Zhang
- Affiliated Hospital of Zunyi Medical College
- Jian Zheng
- The Fifth People’s Hospital of Wuxi
- Dawei Chen
- Baoding Hospital for Infectious Disease
- Xiangyang Yao
- The First Affiliated of XiaMen University
- Tong Ren
- Shenyang Chest Hospital
- Yan Li
- Guang Zhou Chest Hospital
- Yuanyuan Li
- Chest Hospital of Xinjiang
- Lei Wu
- The Third People’s Hospital of Kunming
- Qiang Song
- Shandong Provincial Chest Hospital
- Mei Yang
- Taiyuan Fourth People’s Hospital
- Jian Zhang
- Chang Chun Infectious Diseases Hospital
- Yuanyuan Liu
- Tianjin Haihe Hospital
- Shuliang Guo
- The First Affiliated Hospital of Chongqing Medical University
- Kun Yan
- Weifang No. 2 People’s Hospital
- Xinghua Shen
- The Fifth People’s Hospital of Suzhou
- Dan Lei
- Affiliated Hospital of Zunyi Medical College
- Yanli Zhang
- Baoding Hospital for Infectious Disease
- Youcai Li
- Beijing Chest Hospital
- Yongkang Dong
- Taiyuan Fourth People’s Hospital
- Shenjie Tang
- Beijing Chest Hospital
- DOI
- https://doi.org/10.1155/2023/5562495
- Journal volume & issue
-
Vol. 2023
Abstract
Background. Tuberculosis (TB), a multisystemic disease with protean presentation, remains a major global health problem. Although concurrent pulmonary tuberculosis (PTB) and extrapulmonary tuberculosis (EPTB) cases are commonly observed clinically, knowledge regarding concurrent PTB-EPTB is limited. Here, a large-scale multicenter observational study conducted in China aimed to study the epidemiology of concurrent PTB-EPTB cases by diagnostically defining TB types and then implementing association rules analysis. Methods. The retrospective study was conducted at 21 hospitals in 15 provinces in China and included all inpatients with confirmed TB diagnoses admitted from Jan 2011 to Dec 2017. Association rules analysis was conducted for cases with concurrent PTB and various types of EPTB using the Apriori algorithm. Results. Evaluation of 438,979TB inpatients indicated PTB was the most commonly diagnosed (82.05%) followed by tuberculous pleurisy (23.62%). Concurrent PTB-EPTB was found in 129,422 cases (29.48%) of which tuberculous pleurisy was the most common concurrent EPTB type observed. The multivariable logistic regression models demonstrated that odds ratios of concurrent PTB-EPTB cases varied by gender and age group. For PTB cases with concurrent EPTB, the strongest association was found between PTB and concurrent bronchial tuberculosis (lift = 1.09). For EPTB cases with concurrent PTB, the strongest association was found between pharyngeal/laryngeal tuberculosis and concurrent PTB (lift = 1.11). Confidence and lift values of concurrent PTB-EPTB cases varied with gender and age. Conclusions. Numerous concurrent PTB-EPTB case types were observed, with confidence and lift values varying with gender and age. Clinicians should screen for concurrent PTB-EPTB in order to improve treatment outcomes.
