Nature Communications (Feb 2022)
A platform for oncogenomic reporting and interpretation
- Caralyn Reisle,
- Laura M. Williamson,
- Erin Pleasance,
- Anna Davies,
- Brayden Pellegrini,
- Dustin W. Bleile,
- Karen L. Mungall,
- Eric Chuah,
- Martin R. Jones,
- Yussanne Ma,
- Eleanor Lewis,
- Isaac Beckie,
- David Pham,
- Raphael Matiello Pletz,
- Amir Muhammadzadeh,
- Brandon M. Pierce,
- Jacky Li,
- Ross Stevenson,
- Hansen Wong,
- Lance Bailey,
- Abbey Reisle,
- Matthew Douglas,
- Melika Bonakdar,
- Jessica M. T. Nelson,
- Cameron J. Grisdale,
- Martin Krzywinski,
- Ana Fisic,
- Teresa Mitchell,
- Daniel J. Renouf,
- Stephen Yip,
- Janessa Laskin,
- Marco A. Marra,
- Steven J. M. Jones
Affiliations
- Caralyn Reisle
- Canada’s Michael Smith Genome Sciences Centre
- Laura M. Williamson
- Canada’s Michael Smith Genome Sciences Centre
- Erin Pleasance
- Canada’s Michael Smith Genome Sciences Centre
- Anna Davies
- Canada’s Michael Smith Genome Sciences Centre
- Brayden Pellegrini
- Canada’s Michael Smith Genome Sciences Centre
- Dustin W. Bleile
- Canada’s Michael Smith Genome Sciences Centre
- Karen L. Mungall
- Canada’s Michael Smith Genome Sciences Centre
- Eric Chuah
- Canada’s Michael Smith Genome Sciences Centre
- Martin R. Jones
- Canada’s Michael Smith Genome Sciences Centre
- Yussanne Ma
- Canada’s Michael Smith Genome Sciences Centre
- Eleanor Lewis
- Canada’s Michael Smith Genome Sciences Centre
- Isaac Beckie
- Canada’s Michael Smith Genome Sciences Centre
- David Pham
- Canada’s Michael Smith Genome Sciences Centre
- Raphael Matiello Pletz
- Canada’s Michael Smith Genome Sciences Centre
- Amir Muhammadzadeh
- Canada’s Michael Smith Genome Sciences Centre
- Brandon M. Pierce
- Canada’s Michael Smith Genome Sciences Centre
- Jacky Li
- Canada’s Michael Smith Genome Sciences Centre
- Ross Stevenson
- Canada’s Michael Smith Genome Sciences Centre
- Hansen Wong
- Canada’s Michael Smith Genome Sciences Centre
- Lance Bailey
- Canada’s Michael Smith Genome Sciences Centre
- Abbey Reisle
- Canada’s Michael Smith Genome Sciences Centre
- Matthew Douglas
- Canada’s Michael Smith Genome Sciences Centre
- Melika Bonakdar
- Canada’s Michael Smith Genome Sciences Centre
- Jessica M. T. Nelson
- Canada’s Michael Smith Genome Sciences Centre
- Cameron J. Grisdale
- Canada’s Michael Smith Genome Sciences Centre
- Martin Krzywinski
- Canada’s Michael Smith Genome Sciences Centre
- Ana Fisic
- Department of Medical Oncology, BC Cancer
- Teresa Mitchell
- Department of Medical Oncology, BC Cancer
- Daniel J. Renouf
- Pancreas Centre BC
- Stephen Yip
- Department of Pathology and Laboratory Medicine, Faculty of Medicine, University of British Columbia
- Janessa Laskin
- Department of Medical Oncology, BC Cancer
- Marco A. Marra
- Canada’s Michael Smith Genome Sciences Centre
- Steven J. M. Jones
- Canada’s Michael Smith Genome Sciences Centre
- DOI
- https://doi.org/10.1038/s41467-022-28348-y
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 11
Abstract
The interpretation of somatic variants in cancer is challenging due to the scale and complexity of sequencing data. Here, the authors present PORI, an open-source framework for interpreting somatic variants in cancer using graph knowledge base tools, automated reporting, and manual curation.
