Nature Communications (Mar 2023)

Direct intranodal tonsil vaccination with modified vaccinia Ankara vaccine protects macaques from highly pathogenic SIVmac251

  • Jeffy G. Mattathil,
  • Asisa Volz,
  • Olusegun O. Onabajo,
  • Sean Maynard,
  • Sandra L. Bixler,
  • Xiaoying X. Shen,
  • Diego Vargas-Inchaustegui,
  • Marjorie Robert-Guroff,
  • Celia Lebranche,
  • Georgia Tomaras,
  • David Montefiori,
  • Gerd Sutter,
  • Joseph J. Mattapallil

DOI
https://doi.org/10.1038/s41467-023-36907-0
Journal volume & issue
Vol. 14, no. 1
pp. 1 – 15

Abstract

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Mucosal surfaces are a primary route of HIV entry, yet the compartmentalisation between mucosal and peripheral immune systems remain a challenge for HIV vaccine candidates. Authors utilise a combination of intranodal tonsil MALT and systemic vaccination in the rhesus macaque model to explore immune responses and protection from highly pathogenic simian homologue of HIV.