Cobalt-Catalyzed (Hetero)arylation of Saturated Cyclic Amines with Grignard Reagents

Abstract

(Hetero)aryl substituted saturated cyclic amines are ubiquitous scaffolds in biologically active molecules. Metal-catalyzed cross-couplings between halogeno N-heterocycles and organometallic species are efficient and modular reactions to access these attractive scaffolds. An overview of our work concerning the cobalt-catalyzed arylation of iodo-substituted cyclic amines is presented.

Keywords

• N-heterocycle
• piperidine
• pyrrolidine
• azetidine
• cross-coupling
• cobalt
• Grignard reagent