Deacetylation of serine hydroxymethyl-transferase 2 by SIRT3 promotes colorectal carcinogenesis

Zhen Wei; Jinglue Song; Guanghui Wang; Ximao Cui; Jun Zheng; Yunlan Tang; Xinyuan Chen; Jixi Li; Long Cui; Chen-Ying Liu; Wei Yu

doi:10.1038/s41467-018-06812-y

Nature Communications (Oct 2018)

Deacetylation of serine hydroxymethyl-transferase 2 by SIRT3 promotes colorectal carcinogenesis

Zhen Wei,
Jinglue Song,
Guanghui Wang,
Ximao Cui,
Jun Zheng,
Yunlan Tang,
Xinyuan Chen,
Jixi Li,
Long Cui,
Chen-Ying Liu,
Wei Yu

Affiliations

Zhen Wei: State Key Laboratory of Genetic Engineering and Collaborative Innovation Center for Genetics and Development, School of Life Sciences and Zhongshan Hospital, Fudan University
Jinglue Song: Department of Colorectal and Anal Surgery, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine
Guanghui Wang: Department of Colorectal and Anal Surgery, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine
Ximao Cui: Department of Colorectal and Anal Surgery, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine
Jun Zheng: State Key Laboratory of Genetic Engineering and Collaborative Innovation Center for Genetics and Development, School of Life Sciences and Zhongshan Hospital, Fudan University
Yunlan Tang: State Key Laboratory of Genetic Engineering and Collaborative Innovation Center for Genetics and Development, School of Life Sciences and Zhongshan Hospital, Fudan University
Xinyuan Chen: State Key Laboratory of Genetic Engineering and Collaborative Innovation Center for Genetics and Development, School of Life Sciences and Zhongshan Hospital, Fudan University
Jixi Li: State Key Laboratory of Genetic Engineering and Collaborative Innovation Center for Genetics and Development, School of Life Sciences and Zhongshan Hospital, Fudan University
Long Cui: Department of Colorectal and Anal Surgery, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine
Chen-Ying Liu: Department of Colorectal and Anal Surgery, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine
Wei Yu: State Key Laboratory of Genetic Engineering and Collaborative Innovation Center for Genetics and Development, School of Life Sciences and Zhongshan Hospital, Fudan University

DOI: https://doi.org/10.1038/s41467-018-06812-y
Journal volume & issue: Vol. 9, no. 1
pp. 1 – 16

Abstract

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Serine hydroxymethyltransferase 2 (SHMT2) converts serine to glycine in mitochondria and is upregulated in a variety of cancers. Here the authors show that acetylation of the lysine-95 (K95) residue negatively regulates SHMT2 expression and activity and is deacetylated by SIRT3 in colorectal cancer.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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