Drug Design, Development and Therapy (Feb 2022)
Evaluating the Therapeutic Potential of Ritlecitinib for the Treatment of Alopecia Areata
Abstract
Hassiel Aurelio Ramírez-Marín,1 Antonella Tosti2 1Department of Dermatology, Weill Cornell Medical College, New York, NY, USA; 2Dr. Philip Frost Department of Dermatology and Cutaneous Surgery, University of Miami Miller School of Medicine, Miami, FL, USACorrespondence: Hassiel Aurelio Ramírez-Marín, Department of Dermatology, Weill Cornell Medical College, 413 E 69th St., Rm 920, New York, NY, 10021, USA, Tel +1 646-962-9970 ; +1 52 618 270 8982, Email [email protected]: Alopecia areata (AA) is an autoimmune condition that causes patchy hair loss, affecting up to 147 million people globally. Currently, there are no treatments approved by US Food and Drug Administration (FDA) specific for AA, and there are few effective therapeutic options for widespread and persistent illness. There is an ongoing need for a treatment that demonstrates a good clinical response with a benefit-risk ratio that is suitable for long-term use, especially for patients with chronic, extensive disease. Several clinical trials and case studies that have assessed Janus kinase inhibitors have had encouraging results. Ritlecitinib, a selective JAK3/TEC kinase inhibitor has been demonstrated to inhibit the action of signaling molecules and immune cells that are responsible for hair loss in people with alopecia areata. Furthermore, several clinical trials are investigating the utility of ritlecitinib in patients with vitiligo, rheumatoid arthritis, Crohn’s disease, and ulcerative colitis. Advantages of using ritlecitinib when compared with other non-selective JAK inhibitors include avoiding JAK1/JAK2 inhibition’s clinical repercussions, which include pharmacodynamic effects such as increased cholesterol and liver enzymes, and those related to JAK2 inhibition (thrombocytopenia, anemia). Treatment with Ritlecitinib 50 mg and 30 mg daily for 24 weeks has been shown to induce hair regrowth with a significant proportion of patients reaching SALT 20 (≤ 20% scalp hair loss) after six months of therapy compared to placebo. Additional research is needed for long-term effects.Keywords: alopecia areata, ritlecitinib, PF-06651600, hair loss, skin diseases, JAK inhibitor
