Cancers (Mar 2011)

Predictive and Prognostic Factors in Colorectal Cancer: A Personalized Approach

  • Timothy A. Rockall,
  • Christopher G. Marks,
  • Myutan Kulendran,
  • John F. Stebbing

DOI
https://doi.org/10.3390/cancers3021622
Journal volume & issue
Vol. 3, no. 2
pp. 1622 – 1638

Abstract

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It is an exciting time for all those engaged in the treatment of colorectal cancer. The advent of new therapies presents the opportunity for a personalized approach to the patient. This approach considers the complex genetic mechanisms involved in tumorigenesis in addition to classical clinicopathological staging. The potential predictive and prognostic biomarkers which have stemmed from the study of the genetic basis of colorectal cancer and therapeutics are discussed with a focus on mismatch repair status, KRAS, BRAF, 18qLOH, CIMP and TGF-β.

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