What is idiopathic scoliosis?

Abstract

The lecture, based on long experience of research, addresses controversial issues in spinal deformity together with some generalizations. The term of scoliosis is defined as a violation of the spine morphogenesis during the early embryonic de- velopment, which, in the process of growth, develops into spinal deformity with clinical variants depending on the degree of morphogenesis violation. The etiological factor of scoliosis is ectopic localization of neural crest-derived cells, which are not genetically deterministic to chondrogenesis and the growth process, in the vertebral body growth plates. The lo- cal violation of chondrogenesis in the vertebral body growth plates is a cause of the growth asymmetry and spinal defor- mity development. The variability of structural changes and the progression prediction depend on the degree of violation of morphogenetic processes laid down during embryogenesis. A phenotype of scoliosis is the primary scoliotic or kyphotic deformity of the spine with variants of the disease course depending on its stage. Research Perspective: the creation of an experimental model of scoliosis with clinical variants and the development of pre- ventive correction of the studied pathology.

Keywords

• idiopathic scoliosis
• scoliotic disease
• phenotype
• morphogenesis of the spine