RELATION OF DISTURBANCES IN THE ERYTHROCYTES ELECTRICAL ACTIVITY WITH DYSLIPIDEMIA IN THE METABOLIC SYNDROME

Abstract

Aim. To study the erythrocyte electric charge (EEC) in patients with metabolic syndrome (MS).Material and methods. 112 patients (mean age 61.4±7.2 years) with MS (average duration of MS 8.7±5.2 years) were examined. Control group consisted of healthy volunteers (n=25) of similar age. The level of EEC was detected by the method of adsorption of a positive cationic dye (cationic blue O) on the surface of the erythrocyte plasma membrane up to the complete neutralization of their negative charge, followed by photometry of the solution and calculation of the number of charges on the erythrocyte cell surface. The results of the study were processed by Statistica 10.0 software.Results. Hypertension was found in 73% of patients with MS, hyperglycemia – in 39%, diabetes – in 36%, dyslipidemia – in 80% of patients. The EEC in MS patients (1.59±0.05×107) was lower than this in the control group (1.65±0.03×107; p<0.05). With MS duration more than 5 years, the EEC was significantly lower in comparison with control group (p<0.05). In patients with obesity II-III degrees as well as dyslipidemia the EEC values were significantly lower vs control group (p<0.05). In patients with MS, a significant negative correlation of EEC with total cholesterol (r=-0.51, p<0.05) and triglycerides (r=-0.51, p<0.05) levels were revealed.Conclusion. In patients with MS with increase in the MS duration, degree of obesity and lipid metabolism disorders, significantly lower values of EEC were observed.

Keywords

• metabolic syndrome
• electric charge of erythrocytes
• obesity
• dyslipidemia
• microcirculation