Nature Communications (Jul 2020)

Large-scale DNA-based phenotypic recording and deep learning enable highly accurate sequence-function mapping

  • Simon Höllerer,
  • Laetitia Papaxanthos,
  • Anja Cathrin Gumpinger,
  • Katrin Fischer,
  • Christian Beisel,
  • Karsten Borgwardt,
  • Yaakov Benenson,
  • Markus Jeschek

DOI
https://doi.org/10.1038/s41467-020-17222-4
Journal volume & issue
Vol. 11, no. 1
pp. 1 – 15

Abstract

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Current methods to generate sequence-function data at large scale are either technically complex or limited to specific applications. Here the authors introduce DNA-based phenotypic recording to overcome these limitations and enable deep learning for accurate prediction of function from sequence.