Relationship of subclinical inflammatory markers with glycemic status and duration of diabetes among rural Indian type 2 diabetic population

Abstract

Background: Neutrophil-to-Lymphocyte Ratio (NLR) and the Platelet-to-Lymphocyte Ratio (PLR)are the inflammatory markers in Type 2 Diabetes Mellitus (T2DM) and there are few documented Indian rural studies. The aim of this study is to evaluate the relationship between Neutrophil Lymphocyte Ratio (NLR), Platelet Lymphocyte Ratio (PLR) with glycemic status (HbA1c) and duration of diabetic detection in rural Indian T2DM. Methods: This is a prospective observation study, T2DM between the ages of 30-60 years, attending to Sree Sidhi Vinayaka Diabetic Centre (2013-2019). NLR, PLR was compared with duration of diabetes and glycemic status. T2DM were divided into three groups, Group I with HbA1c 9 [worst control]. Results: 5163 patients attended the clinic, among them, 1303 fulfilled the inclusion criteria. The mean age of T2DM was 47.02±7.81 yrs, with 637 females and 666 males (Male: Female ratio is ≈1). A significant increase in the NLR & PLR levels in T2DM more than 5 years of duration was noted. There is a significant positive strength of association between duration of T2DM, level of HbA1c, PLR and NLR levels. Mean level of NLR & PLR were significantly lower in the Group I diabetics compared with the Group II and Group III (p<0.01), Conclusions: There is significant positive strength of association between glycemic status and duration of diabetes with NLR & PLR as inflammatory marker in rural T2DM.

Keywords

• neutrophil-lymphocyte ratio
• platelet-lymphocyte ratio
• hba1c
• duration of diabetes mellitus
• rural indian population