Frontiers in Cell and Developmental Biology (Jan 2023)

Serum D-dimer is not predictive of placenta-mediated complications in pregnancy at high risk: The multicentric prospective cohort AngioPred study

  • Agathe Hovine,
  • Céline Chauleur,
  • Céline Chauleur,
  • Christophe Gauld,
  • Florence Rancon,
  • Florence Rancon,
  • Jean-Christophe Gris,
  • Jean-Christophe Gris,
  • Jean-Christophe Gris,
  • Brigitte Tardy,
  • Antoine Giraud,
  • Antoine Giraud,
  • Tiphaine Raia-Barjat,
  • Tiphaine Raia-Barjat

DOI
https://doi.org/10.3389/fcell.2023.1115622
Journal volume & issue
Vol. 11

Abstract

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Background: The theory that D-dimer level might has a predictive or diagnostic role in preeclampsia needs to be explored. Aim of the study was to evaluate the association between serum D-dimer level and the occurrence of placenta-mediated complications (PMC) in a pregnant population at high risk.Methods: A prospective multicenter cohort study including 200 pregnant women was conducted.Results: Serum D-dimer increases throughout pregnancy, with the highest levels at the end of gestation. Serum D-dimer level was similar for women with PMC and with no complication. Serum D-dimer level was not different in women with preeclampsia versus uncomplicated women. Serum D-dimer level was not different in women with early or late preeclampsia versus uncomplicated women.Conclusion: This result suggests that serum D-dimer level was not predictive of the PMC occurrence. This corroborates the fact that the origin of PMC based more on immunity than in hemostasis.

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