Plants (Jun 2021)

Phytochemical Analysis of <i>Anvillea garcinii</i> Leaves: Identification of Garcinamines F–H and Their Antiproliferative Activities

  • Hanan Y. Aati,
  • Shagufta Perveen,
  • Raha Orfali,
  • Areej M. Al-Taweel,
  • Jiangnan Peng,
  • Sobia Tabassum,
  • Maged S. Abdel-Kader,
  • Hasan Soliman Yusufoglu,
  • Orazio Taglialatela-Scafati

DOI
https://doi.org/10.3390/plants10061130
Journal volume & issue
Vol. 10, no. 6
p. 1130

Abstract

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Anvillea garcinii is a medicinal plant used in the Arab region for intestinal diseases, lung and liver diseases, digestive problems, and as an antidiabetic agent. Repeated chromatographic purifications of A. garcinii leaves led to the isolation of three undescribed guaiane sesquiterpene derivatives, named garcinamines F–H, characterized by the presence of an amino acid unit, along with five known sesquiterpene lactones (garcinamines B–E and 9β-hydroxyparthenolide). The structures of the new compounds were established using spectroscopic (1D and 2D NMR) and spectrometric methods (ESIMS). Garcinamine H possesses a double bond at the Δ1,10 position, a structural feature rarely reported in guaianolide-type sesquiterpenes. The antiproliferative activity of the isolated sesquiterpenes was screened against three different cancer cell lines, and 9β-hydroxyparthenolide and garcinamines C and D displayed significant effects against lung carcinoma (A549), colon carcinoma (LoVo), and breast carcinoma (MCF7) cell lines.

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